| Tag |
Content |
| dbPAF ID |
dbPAF-0000724 |
| Uniprot Accession |
O14684; PTGES_HUMAN; O14900; Q5SZC0;
|
| Genbank Protein ID |
NP_004869.1;
|
| Genbank Nucleotide ID |
NM_004878.4;
|
| Protein Name |
Prostaglandin E synthase |
| Protein Synonyms/Alias |
Microsomal glutathione S-transferase 1-like 1;MGST1-L1;Microsomal prostaglandin E synthase 1;MPGES-1;p53-induced gene 12 protein; |
| Gene Name |
PTGES |
| Gene Synonyms/Alias |
MGST1L1;MPGES1;PGES;PIG12; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).Functional Description
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 61 | GGPQYCRSDPDVERC | curated | 23898821 |
|
Sequence
(Fasta) | MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA LRHGGPQYCR 60
SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW MHFLVFLVGR VAHTVAYLGK 120
LRAPIRSVTY TLAQLPCASM ALQILWEAAR HL
153Fasta Sequence
>O14684|PTGES|Homo sapiens(Human)
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0413--Isomerase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0643--Prostaglandin biosynthesis
KW-0644--Prostaglandin metabolism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR023352--MAPEG-like_dom
IPR001129--Membr-assoc_MAPEG
|
| PROSITE |
|
| Pfam |
PF01124--MAPEG
|
| Gene Ontology |
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005641--C:nuclear envelope lumen
GO:0048471--C:perinuclear region of cytoplasm
GO:0043295--F:glutathione binding
GO:0050220--F:prostaglandin-E synthase activity
GO:0002526--P:acute inflammatory response
GO:0019369--P:arachidonic acid metabolic process
GO:0002544--P:chronic inflammatory response
GO:0019371--P:cyclooxygenase pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0001516--P:prostaglandin biosynthetic process
GO:0006693--P:prostaglandin metabolic process
GO:0051592--P:response to calcium ion
GO:0034097--P:response to cytokine
GO:0032496--P:response to lipopolysaccharide
GO:0014070--P:response to organic cyclic compound
GO:0032526--P:response to retinoic acid
GO:0007165--P:signal transduction
GO:0044281--P:small molecule metabolic process
|
