dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000722
Uniprot Accession O14682; ENC1_HUMAN; B4DHJ1; E9PFU0; O75464; Q9UPG9;
Genbank Protein ID NP_001243503.1; NP_001243504.1; NP_001243505.1; NP_003624.1; XP_011541998.1; XP_011541999.1;
Genbank Nucleotide ID NM_001256574.1; NM_001256575.1; NM_001256576.1; NM_003633.3; XM_011543696.1; XM_011543697.1;
Protein Name Ectoderm-neural cortex protein 1
Protein Synonyms/Alias
Gene Name ENC1
Gene Synonyms/Alias KLHL37;NRPB;PIG10;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
2------MSVSVHENRPhosphoSitePlus22135298
11SVHENRKSRASSGSIcurated23898821
14ENRKSRASSGSINIYcurated23898821
15NRKSRASSGSINIYLcurated23898821
17KSRASSGSINIYLFHcurated23898821
70VLAACSRYFEAMFSGPhosphoSitePlus22135298
245LALLPAIYLMENVAMdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
304LFLLGGQTFMCDKLYcurated19690332
406ATGCLPASPSVSLKQPhosphoSitePlus;curated22135298; 22817900; 24961811
417SLKQVEHYDPTINKWPhosphoSitePlus22135298
435APLREGVSNAAVVSAdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 22135298
441VSNAAVVSAKLKLFAdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 22135298
452KLFAFGGTSVSHDKLPhosphoSitePlus22135298
453LFAFGGTSVSHDKLPPhosphoSitePlus22135298
455AFGGTSVSHDKLPKVPhosphoSitePlus22135298
569LDVWNSITTVPYSLIdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
570DVWNSITTVPYSLIPdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
573NSITTVPYSLIPTAFdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
Sequence
(Fasta)		MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH 60
RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL 120
LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR 180
KNEDFLQLPQ DMVVQLLSSE ELETEDERLV YESAINWISY DLKKRYCYLP ELLQTVRLAL 240
LPAIYLMENV AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL 300
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS ENGVSKDVWV 360
YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT GCLPASPSVS LKQVEHYDPT 420
INKWTMVAPL REGVSNAAVV SAKLKLFAFG GTSVSHDKLP KVQCYDQCEN RWTVPATCPQ 480
PWRYTAAAVL GNQIFIMGGD TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL 540
YVVGGYFGIQ RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR030562--ENC1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--POZ_dom
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0043025--C:neuronal cell body
GO:0000790--C:nuclear chromatin
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0007275--P:multicellular organismal development
GO:0017148--P:negative regulation of translation
GO:0007399--P:nervous system development
GO:0010976--P:positive regulation of neuron projection development
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0016567--P:protein ubiquitination