| Tag |
Content |
| dbPAF ID |
dbPAF-0000720 |
| Uniprot Accession |
O14678; ABCD4_HUMAN; A8K5L7; Q6IAQ0; Q96E75;
|
| Genbank Protein ID |
NP_005041.1;
|
| Genbank Nucleotide ID |
NM_005050.3;
|
| Protein Name |
ATP-binding cassette sub-family D member 4 |
| Protein Synonyms/Alias |
PMP70-related protein;P70R;Peroxisomal membrane protein 1-like;PXMP1-L;Peroxisomal membrane protein 69;PMP69; |
| Gene Name |
ABCD4 |
| Gene Synonyms/Alias |
PXMP1L; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.Functional Description
May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAVAGPAPGA GARPRLDLQF LQRFLQILKV LFPSWSSQNA LMFLTLLCLT LLEQFVIYQV 60
GLIPSQYYGV LGNKDLEGFK TLTFLAVMLI VLNSTLKSFD QFTCNLLYVS WRKDLTEHLH 120
RLYFRGRAYY TLNVLRDDID NPDQRISQDV ERFCRQLSSM ASKLIISPFT LVYYTYQCFQ 180
STGWLGPVSI FGYFILGTVV NKTLMGPIVM KLVHQEKLEG DFRFKHMQIR VNAEPAAFYR 240
AGHVEHMRTD RRLQRLLQTQ RELMSKELWL YIGINTFDYL GSILSYVVIA IPIFSGVYGD 300
LSPAELSTLV SKNAFVCIYL ISCFTQLIDL STTLSDVAGY THRIGQLRET LLDMSLKSQD 360
CEILGESEWG LDTPPGWPAA EPADTAFLLE RVSISAPSSD KPLIKDLSLK ISEGQSLLIT 420
GNTGTGKTSL LRVLGGLWTS TRGSVQMLTD FGPHGVLFLP QKPFFTDGTL REQVIYPLKE 480
VYPDSGSADD ERILRFLELA GLSNLVARTE GLDQQVDWNW YDVLSPGEMQ RLSFARLFYL 540
QPKYAVLDEA TSALTEEVES ELYRIGQQLG MTFISVGHRQ SLEKFHSLVL KLCGGGRWEL 600
MRIKVE
607Fasta Sequence
>O14678|ABCD4|Homo sapiens(Human)
MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRIKVE
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR027417--P-loop_NTPase
|
| PROSITE |
PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
|
| Pfam |
PF06472--ABC_membrane_2
PF00005--ABC_tran
|
| Gene Ontology |
GO:0043190--C:ATP-binding cassette (ABC) transporter complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0009235--P:cobalamin metabolic process
GO:0044281--P:small molecule metabolic process
GO:0055085--P:transmembrane transport
GO:0006766--P:vitamin metabolic process
GO:0006767--P:water-soluble vitamin metabolic process
|
