| Tag |
Content |
| dbPAF ID |
dbPAF-0000719 |
| Uniprot Accession |
O14672; ADA10_HUMAN; B4DU28; Q10742; Q92650;
|
| Genbank Protein ID |
NP_001101.1;
|
| Genbank Nucleotide ID |
NM_001110.3;
|
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 10 |
| Protein Synonyms/Alias |
|
| Gene Name |
ADAM10 |
| Gene Synonyms/Alias |
KUZ;MADM; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.Functional Description
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL 60
RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI 120
DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE 180
RMRKYQMTGV EEVTQIPQEE HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE 240
AVIAQISSHV KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF 300
LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY SDGKKKSLNT 360
GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT PGESKNLGQK ENGNYIMYAR 420
ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK 480
DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT 540
ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK 600
KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA DGPLARLKKA 660
IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS VHTPSSNPKL PPPKPLPGTL 720
KRRRPPQPIQ QPQRQRPRES YQMGHMRR
749Fasta Sequence
>O14672|ADAM10|Homo sapiens(Human)
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0026--Alzheimer disease
KW-1008--Amyloidosis
KW-1003--Cell membrane
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0523--Neurodegeneration
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0729--SH3-binding
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0865--Zymogen
|
| Interpro |
IPR027053--ADAM_10
IPR001762--Disintegrin_dom
IPR024079--MetalloPept_cat_dom
IPR001590--Peptidase_M12B
IPR002870--Peptidase_M12B_N
|
| PROSITE |
PS50215--ADAM_MEPRO
PS50214--DISINTEGRIN_2
PS00142--ZINC_PROTEASE
|
| Pfam |
PF00200--Disintegrin
PF01562--Pep_M12B_propep
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005798--C:Golgi-associated vesicle
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0097038--C:perinuclear endoplasmic reticulum
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0097197--C:tetraspanin-enriched microdomain
GO:0004175--F:endopeptidase activity
GO:0005178--F:integrin binding
GO:0004222--F:metalloendopeptidase activity
GO:0008237--F:metallopeptidase activity
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0005102--F:receptor binding
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0007267--P:cell-cell signaling
GO:0030574--P:collagen catabolic process
GO:0051089--P:constitutive protein ectodomain proteolysis
GO:0048013--P:ephrin receptor signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0022617--P:extracellular matrix disassembly
GO:0030198--P:extracellular matrix organization
GO:0001701--P:in utero embryonic development
GO:0007229--P:integrin-mediated signaling pathway
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0042117--P:monocyte activation
GO:0007162--P:negative regulation of cell adhesion
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0051088--P:PMA-inducible membrane protein ectodomain proteolysis
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0010820--P:positive regulation of T cell chemotaxis
GO:0006468--P:protein phosphorylation
GO:0034612--P:response to tumor necrosis factor
|
