dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000711
Uniprot Accession O14649; KCNK3_HUMAN; Q53SU2;
Genbank Protein ID NP_002237.1;
Genbank Nucleotide ID NM_002246.2;
Protein Name Potassium channel subfamily K member 3
Protein Synonyms/Alias Acid-sensitive potassium channel protein TASK-1;TWIK-related acid-sensitive K(+) channel 1;Two pore potassium channel KT3.1;Two pore K(+) channel KT3.1;
Gene Name KCNK3
Gene Synonyms/Alias TASK;TASK1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
113GKVFCMFYALLGIPLcurated25850435
300GGGFRNVYAEVLHFQPhosphoSitePlus22135298
315SMCSCLWYKSREKLQPhosphoSitePlus22135298
323KSREKLQYSIPMIIPPhosphoSitePlus;curated22135298; 22817900
335IIPRDLSTSDTCVEQPhosphoSitePlus22135298
336IPRDLSTSDTCVEQSPhosphoSitePlus22135298
358GRYSDTPSRRCLCSGPhosphoSitePlus;curated22135298; 22817900
364PSRRCLCSGAPRSAIPhosphoSitePlus22135298
369LCSGAPRSAISSVSTPhosphoSitePlus22135298
383TGLHSLSTFRGLMKRPhosphoSitePlus;curated22135298; 22817900
392RGLMKRRSSV-----PhosphoSitePlus22135298
393GLMKRRSSV------PhosphoSitePlus22135298
Sequence
(Fasta)		MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA RYNLSQGGYE 60
ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA PSTDGGKVFC MFYALLGIPL 120
TLVMFQSLGE RINTLVRYLL HRAKKGLGMR RADVSMANMV LIGFFSCIST LCIGAAAFSH 180
YEHWTFFQAY YYCFITLTTI GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN 240
LVVLRFMTMN AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY 300
AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG GRYSDTPSRR 360
CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV 395
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0630--Potassium
KW-0631--Potassium channel
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR003280--2pore_dom_K_chnl
IPR003092--2pore_dom_K_chnl_TASK
IPR013099--K_chnl_dom
IPR005406--KCNK3
PROSITE
Pfam

PF07885--Ion_trans_2
Gene Ontology

GO:0005829--C:cytosol
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005216--F:ion channel activity
GO:0005252--F:open rectifier potassium channel activity
GO:0005267--F:potassium channel activity
GO:0022841--F:potassium ion leak channel activity
GO:0044548--F:S100 protein binding
GO:0007420--P:brain development
GO:0071456--P:cellular response to hypoxia
GO:0071294--P:cellular response to zinc ion
GO:0090102--P:cochlea development
GO:0034220--P:ion transmembrane transport
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0051481--P:negative regulation of cytosolic calcium ion concentration
GO:0071805--P:potassium ion transmembrane transport
GO:0006813--P:potassium ion transport
GO:0042493--P:response to drug
GO:0030322--P:stabilization of membrane potential
GO:0007268--P:synaptic transmission