dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000710
Uniprot Accession O14647; CHD2_HUMAN; C6G482; Q96IP5;
Genbank Protein ID NP_001036037.1; NP_001262.3;
Genbank Nucleotide ID NM_001042572.2; NM_001271.3;
Protein Name Chromodomain-helicase-DNA-binding protein 2
Protein Synonyms/Alias
Gene Name CHD2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 63 (View all)
PositionPeptidesSourceReferences ( PMIDs )
129FNIKEEASSGSESGScurated20873877; 23663014; 25849741
130NIKEEASSGSESGSPcurated20873877; 23663014; 25849741
132KEEASSGSESGSPKRcurated20873877; 23663014; 25849741
134EASSGSESGSPKRRGcurated23663014
136SSGSESGSPKRRGQRPhosphoSitePlus;curated22135298; 23663014; 25849741
156EKWKQEPSEDEQEQGdbPTM 3.0;PhosphoSitePlus;curated21406692; 22115753; 16381945; 23193290; 22135298; 23090842;
164EDEQEQGTSAESEPEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated21406692; 16381945; 23193290; 18691976; 18988627; 22135298;
165DEQEQGTSAESEPEQdbPTM 3.0;PhosphoSitePlus;curated21406692; 22115753; 16381945; 23193290; 22135298; 22817900
168EQGTSAESEPEQKKVdbPTM 3.0;PhosphoSitePlus;curated21406692; 22115753; 16381945; 23193290; 22135298; 23090842;
207GKRKKQDSSDEDDDDdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20068231; 21406692; 16381945; 23193290; 19651622; 18988627;
208KRKKQDSSDEDDDDDdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20068231; 21406692; 16381945; 23193290; 19651622; 18988627;
240KEDDDFETDSDDLIEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 18691976; 16381945; 23193290; 21406692; 18452278;
242DDDFETDSDDLIEMTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 18691976; 16381945; 23193290; 21406692; 18452278;
249SDDLIEMTGEGVDEQcurated25849741
262EQQDNSETIEKVLDSPhosphoSitePlus22135298
269TIEKVLDSRLGKKGAPhosphoSitePlus22135298
282GATGASTTVYAIEANPhosphoSitePlus22135298
596FNALITTYEILLKDKPhosphoSitePlus;curated22135298; 22817900
737KWILTRNYKALAKGTdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
747LAKGTRGSTSGFLNIdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18988627; 21081558; 22135298;
Sequence
(Fasta)		MMRNKDKSQE EDSSLHSNAS SHSASEEASG SDSGSQSESE QGSDPGSGHG SESNSSSESS 60
ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW EEYPDVYGVR RSNRSRQEPS 120
RFNIKEEASS GSESGSPKRR GQRQLKKQEK WKQEPSEDEQ EQGTSAESEP EQKKVKARRP 180
VPRRTVPKPR VKKQPKTQRG KRKKQDSSDE DDDDDEAPKR QTRRRAAKNV SYKEDDDFET 240
DSDDLIEMTG EGVDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAIEANG DPSGDFDTEK 300
DEGEIQYLIK WKGWSYIHST WESEESLQQQ KVKGLKKLEN FKKKEDEIKQ WLGKVSPEDV 360
EYFNCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA HSRKPAPSNE PEYLCKWMGL 420
PYSECSWEDE ALIGKKFQNC IDSFHSRNNS KTIPTRECKA LKQRPRFVAL KKQPAYLGGE 480
NLELRDYQLE GLNWLAHSWC KNNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV 540
PLSTLTSWQR EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL 600
KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ NSLKELWSLL 660
HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR VKKDVEKSLP AKVEQILRVE 720
MSALQKQYYK WILTRNYKAL AKGTRGSTSG FLNIVMELKK CCNHCYLIKP PEENERENGQ 780
EILLSLIRSS GKLILLDKLL TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS 840
IKGEIRKQAL DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR 900
AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTI LENNSGRSNS 960
NPFNKEELTA ILKFGAEDLF KELEGEESEP QEMDIDEILR LAETRENEVS TSATDELLSQ 1020
FKVANFATME DEEELEERPH KDWDEIIPEE QRKKVEEEER QKELEEIYML PRIRSSTKKA 1080
QTNDSDSDTE SKRQAQRSSA SESETEDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI 1140
KAYKKFGLPL ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKENASEGK 1200
GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC RVKAAHFDVE 1260
WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE TDKKPQGKQL QTRADYLLKL 1320
LRKGLEKKGA VTGGEEAKLK KRKPRVKKEN KVPRLKEEHG IELSSPRHSD NPSEEGEVKD 1380
DGLEKSPMKK KQKKKENKEN KEKQMSSRKD KEGDKERKKS KDKKEKPKSG DAKSSSKSKR 1440
SQGPVHITAG SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLNVQEQLE 1500
HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK LYKMAHKKRS 1560
QEEEEQKKKD DVTGGKKPFR PEASGSSRDS LISQSHTSHN LHPQKPHLPA SHGPQMHGHP 1620
RDNYNHPNKR HFSNADRGDW QRERKFNYGG GNNNPPWGSD RHHQYEQHWY KDHHYGDRRH 1680
MDAHRSGSYR PNNMSRKRPY DQYSSDRDHR GHRDYYDRHH HDSKRRRSDE FRPQNYHQQD 1740
FRRMSDHRPA MGYHGQGPSD HYRSFHTDKL GEYKQPLPPL HPAVSDPRSP PSQKSPHDSK 1800
SPLDHRSPLE RSLEQKNNPD YNWNVRKT 1829
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0887--Epilepsy
KW-0347--Helicase
KW-0378--Hydrolase
KW-0517--Myogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR030485--CHD2
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR025260--DUF4208
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00385--Chromo
PF13907--DUF4208
PF00271--Helicase_C
PF00176--SNF2_N
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0044822--F:poly(A) RNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016568--P:chromatin modification
GO:0032508--P:DNA duplex unwinding
GO:0060218--P:hematopoietic stem cell differentiation
GO:0007517--P:muscle organ development
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated