dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000707
Uniprot Accession O14641; DVL2_HUMAN; D3DTN3; Q53XM0;
Genbank Protein ID NP_004413.1;
Genbank Nucleotide ID NM_004422.2;
Protein Name Segment polarity protein dishevelled homolog DVL-2
Protein Synonyms/Alias
Gene Name DVL2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 72 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MAGSSTGGGGVcurated25849741
6--MAGSSTGGGGVGEcurated23403867
14GGGGVGETKVIYHLDPhosphoSitePlus;curated22135298; 23403867
18VGETKVIYHLDEEETdbPTM 3.0;PhosphoSitePlus;curated19920076; 16381945; 23193290; 22135298; 22817900
27LDEEETPYLVKIPVPdbPTM 3.0;PhosphoSitePlus;curated19920076; 16381945; 23193290; 22135298; 22817900
39PVPAERITLGDFKSVPhosphoSitePlus22135298
59GAKYFFKSMDQDFGVPhosphoSitePlus22135298
135IGDSRPPSFHPNVSSPhosphoSitePlus22135298
142SFHPNVSSSHENLEPPhosphoSitePlus;curated22135298; 23186163
143FHPNVSSSHENLEPEdbPTM 3.0;PhosphoSitePlus;curated19276368; 22609948; 16381945; 23193290; 22135298; 22817900
151HENLEPETETESVVSPhosphoSitePlus22135298
153NLEPETETESVVSLRPhosphoSitePlus22135298
155EPETETESVVSLRREPhosphoSitePlus22135298
158TETESVVSLRRERPRPhosphoSitePlus22135298
169ERPRRRDSSEHGAGGdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
170RPRRRDSSEHGAGGHdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
192LERHLAGYESSSTLMcurated19690332
194RHLAGYESSSTLMTScurated19690332
195HLAGYESSSTLMTSEdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900
196LAGYESSSTLMTSELdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL 120
PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG 180
GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR 240
KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 360
AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 420
TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 480
GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 540
GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 600
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA 660
HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS 720
FHMAMGNPSE FFVDVM 737
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0217--Developmental protein
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0879--Wnt signaling pathway
Interpro

IPR000591--DEP_dom
IPR024580--Dishevelled_C-dom
IPR008339--Dishevelled_fam
IPR003351--Dishevelled_protein_dom
IPR001158--DIX
IPR015506--Dsh/Dvl-rel
IPR008341--DVL2
IPR001478--PDZ
IPR029071--Ubiquitin-rel_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50186--DEP
PS50841--DIX
PS50106--PDZ
Pfam

PF00610--DEP
PF02377--Dishevelled
PF00778--DIX
PF12316--Dsh_C
PF00595--PDZ
Gene Ontology

GO:0045177--C:apical part of cell
GO:0045334--C:clathrin-coated endocytic vesicle
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005109--F:frizzled binding
GO:0042802--F:identical protein binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0044340--P:canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0034613--P:cellular protein localization
GO:0090103--P:cochlea morphogenesis
GO:0022007--P:convergent extension involved in neural plate elongation
GO:0007507--P:heart development
GO:0035329--P:hippo signaling
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0001843--P:neural tube closure
GO:0035567--P:non-canonical Wnt signaling pathway
GO:0003151--P:outflow tract morphogenesis
GO:0090179--P:planar cell polarity pathway involved in neural tube closure
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0043507--P:positive regulation of JUN kinase activity
GO:0001934--P:positive regulation of protein phosphorylation
GO:0061098--P:positive regulation of protein tyrosine kinase activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0007379--P:segment specification
GO:0007264--P:small GTPase mediated signal transduction
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway