dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000706
Uniprot Accession O14640; DVL1_HUMAN; Q5TA33; Q5TA35;
Genbank Protein ID NP_004412.2; XP_005244788.1;
Genbank Nucleotide ID NM_004421.2; XM_005244731.2;
Protein Name Segment polarity protein dishevelled homolog DVL-1
Protein Synonyms/Alias
Gene Name DVL1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Phosphorylation Sites
 dbPAF PTMs: 26 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MAETKIIYHMDcurated23663014
8MAETKIIYHMDEEETPhosphoSitePlus;curated22135298; 23663014
15YHMDEEETPYLVKLPcurated23663014
17MDEEETPYLVKLPVAPhosphoSitePlus;curated22135298; 23663014
51AYKFFFKSMDQDFGVcurated23090842
79CFNGRVVSWLVLAEGPhosphoSitePlus22135298
89VLAEGAHSDAGSQGTPhosphoSitePlus;curated22135298; 20873877
93GAHSDAGSQGTDSHTdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18077418; 16381945; 23193290; 18988627; 22135298; 20873877;
96SDAGSQGTDSHTDLPPhosphoSitePlus;curated22135298; 20873877
98AGSQGTDSHTDLPPPPhosphoSitePlus;curated22135298; 20873877
100SQGTDSHTDLPPPLEPhosphoSitePlus;curated22135298; 20873877
109LPPPLERTGGIGDSRPhosphoSitePlus22135298
188ALSSELESSSFVDSDPhosphoSitePlus22135298
189LSSELESSSFVDSDEPhosphoSitePlus22135298
190SSELESSSFVDSDEDPhosphoSitePlus22135298
279DRGDGGIYIGSIMKGcurated22817900
282DGGIYIGSIMKGGAVPhosphoSitePlus22135298
390SSAVTRTSSSSLTSSPhosphoSitePlus22135298
600RAAGAGGSGSESDHTdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 25627689; 23898821
602AGAGGSGSESDHTAPPhosphoSitePlus;curated22135298; 25627689; 23898821
Sequence
(Fasta)		MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 60
EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 120
HPNVASSRDG MDNETGTESM VSHRRERARR RNREEAARTN GHPRGDRRRD VGLPPDSAST 180
ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI 240
TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP RADPVRPIDP 360
AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG APQLEEAPLT VKSDMSAVVR 420
VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSLLKHGFL 480
RHTVNKITFS EQCYYVFGDL CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY 540
QYPGPPPCFP PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS 600
GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA YTVVGGPPGG 660
PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM 696
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0217--Developmental protein
KW-0242--Dwarfism
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0879--Wnt signaling pathway
Interpro

IPR000591--DEP_dom
IPR024580--Dishevelled_C-dom
IPR008339--Dishevelled_fam
IPR003351--Dishevelled_protein_dom
IPR001158--DIX
IPR015506--Dsh/Dvl-rel
IPR008340--DVL-1
IPR001478--PDZ
IPR029071--Ubiquitin-rel_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50186--DEP
PS50841--DIX
PS50106--PDZ
Pfam

PF00610--DEP
PF02377--Dishevelled
PF00778--DIX
PF12316--Dsh_C
PF00595--PDZ
Gene Ontology

GO:0030424--C:axon
GO:0030136--C:clathrin-coated vesicle
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0030426--C:growth cone
GO:0005874--C:microtubule
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0019899--F:enzyme binding
GO:0005109--F:frizzled binding
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0048675--P:axon extension
GO:0007411--P:axon guidance
GO:0060070--P:canonical Wnt signaling pathway
GO:0090103--P:cochlea morphogenesis
GO:0048668--P:collateral sprouting
GO:0022007--P:convergent extension involved in neural plate elongation
GO:0031122--P:cytoplasmic microtubule organization
GO:0048813--P:dendrite morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0032091--P:negative regulation of protein binding
GO:0006469--P:negative regulation of protein kinase activity
GO:0021915--P:neural tube development
GO:0007528--P:neuromuscular junction development
GO:0007269--P:neurotransmitter secretion
GO:0090179--P:planar cell polarity pathway involved in neural tube closure
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934--P:positive regulation of protein phosphorylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0060134--P:prepulse inhibition
GO:0035372--P:protein localization to microtubule
GO:0034504--P:protein localization to nucleus
GO:0050821--P:protein stabilization
GO:0043113--P:receptor clustering
GO:1903827--P:regulation of cellular protein localization
GO:0001505--P:regulation of neurotransmitter levels
GO:0071340--P:skeletal muscle acetylcholine-gated channel clustering
GO:0035176--P:social behavior
GO:0050808--P:synapse organization
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway