dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000704
Uniprot Accession O14638; ENPP3_HUMAN; Q5JTL3;
Genbank Protein ID NP_005012.2;
Genbank Nucleotide ID NM_005021.4;
Protein Name Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Protein Synonyms/Alias
Gene Name ENPP3
Gene Synonyms/Alias PDNP3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
4----MESTLTLATEQcurated23663014
6--MESTLTLATEQPVcurated23663014
9ESTLTLATEQPVKKNcurated23663014
201SKYMRAMYPTKTFPNcurated25852190
203YMRAMYPTKTFPNHYcurated25852190
205RAMYPTKTFPNHYTIdbPTM 3.0;PhosphoSitePlus;curated7505270; 16381945; 23193290; 22135298; 22817900
389KMEYMTDYFPRINFFPhosphoSitePlus22135298
689YLADKNITHGFLYPPPhosphoSitePlus22135298
694NITHGFLYPPASNRTPhosphoSitePlus22135298
755GPIFDYNYDGHFDAPdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
846VRDVELLTGLDFYQDdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900
851LLTGLDFYQDKVQPVdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900
867EILQLKTYLPTFETTdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MESTLTLATE QPVKKNTLKK YKIACIVLLA LLVIMSLGLG LGLGLRKLEK QGSCRKKCFD 60
ASFRGLENCR CDVACKDRGD CCWDFEDTCV ESTRIWMCNK FRCGETRLEA SLCSCSDDCL 120
QRKDCCADYK SVCQGETSWL EENCDTAQQS QCPEGFDLPP VILFSMDGFR AEYLYTWDTL 180
MPNINKLKTC GIHSKYMRAM YPTKTFPNHY TIVTGLYPES HGIIDNNMYD VNLNKNFSLS 240
SKEQNNPAWW HGQPMWLTAM YQGLKAATYF WPGSEVAING SFPSIYMPYN GSVPFEERIS 300
TLLKWLDLPK AERPRFYTMY FEEPDSSGHA GGPVSARVIK ALQVVDHAFG MLMEGLKQRN 360
LHNCVNIILL ADHGMDQTYC NKMEYMTDYF PRINFFYMYE GPAPRIRAHN IPHDFFSFNS 420
EEIVRNLSCR KPDQHFKPYL TPDLPKRLHY AKNVRIDKVH LFVDQQWLAV RSKSNTNCGG 480
GNHGYNNEFR SMEAIFLAHG PSFKEKTEVE PFENIEVYNL MCDLLRIQPA PNNGTHGSLN 540
HLLKVPFYEP SHAEEVSKFS VCGFANPLPT ESLDCFCPHL QNSTQLEQVN QMLNLTQEEI 600
TATVKVNLPF GRPRVLQKNV DHCLLYHREY VSGFGKAMRM PMWSSYTVPQ LGDTSPLPPT 660
VPDCLRADVR VPPSESQKCS FYLADKNITH GFLYPPASNR TSDSQYDALI TSNLVPMYEE 720
FRKMWDYFHS VLLIKHATER NGVNVVSGPI FDYNYDGHFD APDEITKHLA NTDVPIPTHY 780
FVVLTSCKNK SHTPENCPGW LDVLPFIIPH RPTNVESCPE GKPEALWVEE RFTAHIARVR 840
DVELLTGLDF YQDKVQPVSE ILQLKTYLPT FETTI 876
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
Interpro

IPR017849--Alkaline_Pase-like_a/b/a
IPR017850--Alkaline_phosphatase_core
IPR001604--DNA/RNA_non-sp_Endonuclease
IPR024873--E-NPP
IPR029885--ENPP3
IPR020821--Extracellular_endonuc_su_A
IPR002591--Phosphodiest/P_Trfase
IPR001212--Somatomedin_B_dom
PROSITE

PS00524--SMB_1
PS50958--SMB_2
Pfam

PF01223--Endonuclease_NS
PF01663--Phosphodiest
PF01033--Somatomedin_B
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005887--C:integral component of plasma membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0046872--F:metal ion binding
GO:0035529--F:NADH pyrophosphatase activity
GO:0003676--F:nucleic acid binding
GO:0047429--F:nucleoside-triphosphate diphosphatase activity
GO:0004551--F:nucleotide diphosphatase activity
GO:0004528--F:phosphodiesterase I activity
GO:0030247--F:polysaccharide binding
GO:0005044--F:scavenger receptor activity
GO:0006955--P:immune response
GO:0090305--P:nucleic acid phosphodiester bond hydrolysis
GO:0009143--P:nucleoside triphosphate catabolic process
GO:0006796--P:phosphate-containing compound metabolic process