| Tag |
Content |
| dbPAF ID |
dbPAF-0000702 |
| Uniprot Accession |
O14625; CXL11_HUMAN; Q53YA3; Q92840;
|
| Genbank Protein ID |
NP_001289052.1; NP_005400.1;
|
| Genbank Nucleotide ID |
NM_001302123.1; NM_005409.4;
|
| Protein Name |
C-X-C motif chemokine 11 |
| Protein Synonyms/Alias |
Beta-R1;H174;Interferon gamma-inducible protein 9;IP-9;Interferon-inducible T-cell alpha chemoattractant;I-TAC;Small-inducible cytokine B11; |
| Gene Name |
CXCL11 |
| Gene Synonyms/Alias |
ITAC;SCYB11;SCYB9B; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.Functional Description
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI 60
EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
95Fasta Sequence
>O14625|CXCL11|Homo sapiens(Human)
MSVKGMAIALAVILCATVVQGFPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF
|
| Keyword |
KW-0002--3D-structure
KW-0145--Chemotaxis
KW-0164--Citrullination
KW-0181--Complete proteome
KW-0202--Cytokine
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0395--Inflammatory response
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR001089--Chemokine_CXC
IPR018048--Chemokine_CXC_CS
IPR001811--Chemokine_IL8-like_dom
IPR027221--CXCL11
|
| PROSITE |
PS00471--SMALL_CYTOKINES_CXC
|
| Pfam |
PF00048--IL8
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0008009--F:chemokine activity
GO:0048248--F:CXCR3 chemokine receptor binding
GO:0008201--F:heparin binding
GO:0007267--P:cell-cell signaling
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0030816--P:positive regulation of cAMP metabolic process
GO:0043950--P:positive regulation of cAMP-mediated signaling
GO:0002690--P:positive regulation of leukocyte chemotaxis
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0042127--P:regulation of cell proliferation
GO:0032496--P:response to lipopolysaccharide
GO:0007165--P:signal transduction
GO:0010818--P:T cell chemotaxis
|
