| Tag |
Content |
| dbPAF ID |
dbPAF-0000701 |
| Uniprot Accession |
O14618; CCS_HUMAN; Q2M366; Q8NEV0;
|
| Genbank Protein ID |
NP_005116.1;
|
| Genbank Nucleotide ID |
NM_005125.1;
|
| Protein Name |
Copper chaperone for superoxide dismutase |
| Protein Synonyms/Alias |
Superoxide dismutase copper chaperone; |
| Gene Name |
CCS |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Delivers copper to copper zinc superoxide dismutase (SOD1).Functional Description
Delivers copper to copper zinc superoxide dismutase (SOD1). |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ 60
EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID 120
GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI 180
FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP 240
KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL
275Fasta Sequence
>O14618|CCS|Homo sapiens(Human)
MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL
|
| Keyword |
KW-0002--3D-structure
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0186--Copper
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
|
| Interpro |
IPR024142--Ccs1
IPR006121--HMA_dom
IPR024134--SOD_Cu/Zn_/chaperone
IPR018152--SOD_Cu/Zn_BS
IPR001424--SOD_Cu_Zn_dom
|
| PROSITE |
PS50846--HMA_2
PS00332--SOD_CU_ZN_2
|
| Pfam |
PF00403--HMA
PF00080--Sod_Cu
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005507--F:copper ion binding
GO:0015035--F:protein disulfide oxidoreductase activity
GO:0004784--F:superoxide dismutase activity
GO:0016532--F:superoxide dismutase copper chaperone activity
GO:0008270--F:zinc ion binding
GO:0035434--P:copper ion transmembrane transport
GO:0015680--P:intracellular copper ion transport
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0019430--P:removal of superoxide radicals
GO:0000302--P:response to reactive oxygen species
GO:0006801--P:superoxide metabolic process
|
