dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000700
Uniprot Accession O14617; AP3D1_HUMAN; O00202; O75262; Q59HF5; Q96G11; Q9H3C6;
Genbank Protein ID NP_001248755.1; NP_003929.4;
Genbank Nucleotide ID NM_001261826.1; NM_003938.6;
Protein Name AP-3 complex subunit delta-1
Protein Synonyms/Alias AP-3 complex subunit delta;Adaptor-related protein complex 3 subunit delta-1;Delta-adaptin;
Gene Name AP3D1
Gene Synonyms/Alias PRO0039;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Phosphorylation Sites
 dbPAF PTMs: 35 (View all)
PositionPeptidesSourceReferences ( PMIDs )
9ALKMVKGSIDRMFDKdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 25627689; 25003641
180VFLKYPESLRPAFPRcurated22817900
270LTNLIHSTSAMSLLYPhosphoSitePlus22135298
355CLDDKDESIRLRALDPhosphoSitePlus22135298
365LRALDLLYGMVSKKNPhosphoSitePlus;curated22135298; 22817900
369DLLYGMVSKKNLMEIdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
597VPVAEEVSALFAGELdbPTM 3.018669648; 16381945; 23193290
632AWINEPLSDSESEDEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 20068231; 21406692;
634INEPLSDSESEDERPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 20068231; 20363803;
636EPLSDSESEDERPRAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 20068231; 20363803;
658RRPKHRPSEADEEELdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20166139; 20363803;
682EQANNPFYIKSSPSPPhosphoSitePlus;curated22135298; 25627689; 23403867; 26074081
685NNPFYIKSSPSPQKRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 25627689;
686NPFYIKSSPSPQKRYdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
688FYIKSSPSPQKRYQDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
693SPSPQKRYQDTPGVEcurated26074081
696PQKRYQDTPGVEHIPPhosphoSitePlus;curated22135298; 25627689
721KVPGLPMSDQYVKLEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18988627; 22135298; 25850435;
724GLPMSDQYVKLEEERPhosphoSitePlus;curated22135298; 25627689
758KKGKRRHSSLPTESDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 17081983; 20068231; 18988627;
Sequence
(Fasta)		MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 60
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 120
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 180
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 240
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 300
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 360
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 420
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 480
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 540
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 600
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 660
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 720
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 780
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 840
SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE 900
AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI 960
LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT 1020
LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS 1080
FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS 1140
NLLEEMKATL AKC 1154
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR010474--BLV_receptor
IPR002553--Clathrin/coatomer_adapt-like_N
PROSITE
Pfam

PF01602--Adaptin_N
PF06375--BLVR
Gene Ontology

GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0030117--C:membrane coat
GO:0005654--C:nucleoplasm
GO:0043195--C:terminal bouton
GO:0005215--F:transporter activity
GO:0008089--P:anterograde axon cargo transport
GO:0048490--P:anterograde synaptic vesicle transport
GO:0048007--P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0035646--P:endosome to melanosome transport
GO:0006726--P:eye pigment biosynthetic process
GO:0006886--P:intracellular protein transport
GO:0032438--P:melanosome organization
GO:0051138--P:positive regulation of NK T cell differentiation
GO:0072657--P:protein localization to membrane
GO:0033365--P:protein localization to organelle
GO:0061088--P:regulation of sequestering of zinc ion
GO:0048499--P:synaptic vesicle membrane organization