dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000699
Uniprot Accession O14613; BORG1_HUMAN; B2RD85; Q9UNS0;
Genbank Protein ID NP_006770.1;
Genbank Nucleotide ID NM_006779.3;
Protein Name Cdc42 effector protein 2
Protein Synonyms/Alias Binder of Rho GTPases 1;
Gene Name CDC42EP2
Gene Synonyms/Alias BORG1;CEP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
2------MSTKVPIYLcurated25404012
3-----MSTKVPIYLKcurated23186163
8MSTKVPIYLKRGSRKPhosphoSitePlus22135298
26EKLRDLLSSDMISPPPhosphoSitePlus22135298
31LLSSDMISPPLGDFRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 18988627; 21081558; 22135298;
88LPFQFTRTATVCGREdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
90FQFTRTATVCGRELPdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
101RELPDGPSPLLKNAIdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18988627; 21081558; 22135298;
109PLLKNAISLPVIGGPcurated25850435
137PPRLHLETPQPSPQEPhosphoSitePlus;curated22135298; 23898821; 20873877; 21857030
141HLETPQPSPQEGGSVdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 20068231; 18988627; 21081558;
Sequence
(Fasta)		MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGSD MFGDISFLQG 60
KFHLLPGTMV EGPEEDGTFD LPFQFTRTAT VCGRELPDGP SPLLKNAISL PVIGGPQALT 120
LPTAQAPPKP PRLHLETPQP SPQEGGSVDI WRIPETGSPN SGLTPESGAE EPFLSNASSL 180
LSLHVDLGPS ILDDVLQIMD QDLDSMQIPT 211
Keyword

KW-0007--Acetylation
KW-0133--Cell shape
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR029273--Cdc42_effect
IPR017363--Cdc42_effector_prot_2
IPR000095--CRIB_dom
PROSITE

PS50108--CRIB
Pfam

PF14957--BORG_CEP
PF00786--PBD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005886--C:plasma membrane
GO:0017049--F:GTP-Rho binding
GO:0005096--F:GTPase activator activity
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0030838--P:positive regulation of actin filament polymerization
GO:0043547--P:positive regulation of GTPase activity
GO:0031334--P:positive regulation of protein complex assembly
GO:0031274--P:positive regulation of pseudopodium assembly
GO:0008360--P:regulation of cell shape
GO:0007266--P:Rho protein signal transduction