dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000698
Uniprot Accession O14607; UTY_HUMAN; A8K9Z3; E1U199; E1U1A0; F5H4V7; F8W8R7; O14608;
Genbank Protein ID NP_001245181.1; NP_001245183.1; NP_009056.3; NP_872600.1; NP_872601.1;
Genbank Nucleotide ID NM_001258252.1; NM_001258254.1; NM_007125.4; NM_182659.1; NM_182660.1;
Protein Name Histone demethylase UTY
Protein Synonyms/Alias Ubiquitously-transcribed TPR protein on the Y chromosome;Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein;
Gene Name UTY
Gene Synonyms/Alias KDM6C;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
28KMAEGKASRESEEESPhosphoSitePlus22135298
386KRCSNTSTLAARIKFPhosphoSitePlus22135298
421QVYSLCLTPQKLQHLcurated26074081
586EPWRKQLSNSAQGLHPhosphoSitePlus22135298
588WRKQLSNSAQGLHKSPhosphoSitePlus22135298
674SKPSKNRSLVPETSRPhosphoSitePlus22135298
679NRSLVPETSRHTGDTPhosphoSitePlus22135298
680RSLVPETSRHTGDTSPhosphoSitePlus22135298
683VPETSRHTGDTSNGCPhosphoSitePlus22135298
765TDHSVASSPSSAISTcurated23090842; 26074081
771SSPSSAISTATPSPKcurated23090842
774SSAISTATPSPKSTEHPRD 9;PhosphoSitePlus19413330; 18988627; 22135298
776AISTATPSPKSTEQRPhosphoSitePlus;curated22135298; 23090842; 22817900
887KDKLNPPTPSIYLENUniProt24798337
1033FKTIKFGTNIDLSDNdbPTM 3.0;HPRD 9;PhosphoSitePlus18491316; 16381945; 23193290; 18988627; 22135298
1038FGTNIDLSDNKKWKLdbPTM 3.0;HPRD 9;PhosphoSitePlus18491316; 16381945; 23193290; 18988627; 22135298
1078HTILGMNTVQLYMKVPhosphoSitePlus22135298
1213NKLKSVKSPVPMVHLPhosphoSitePlus22135298
1231MARNIKVSDPKLFEMPhosphoSitePlus22135298
Sequence
(Fasta)		MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 60
EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 120
ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 180
KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 240
TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 300
FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 360
SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 420
TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 480
SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 540
LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 600
SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 660
IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 720
IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 780
EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 840
TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 900
PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 960
PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR 1020
RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ 1080
LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW 1140
WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV 1200
ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK YCLLKILKQY QTLREALVAA 1260
GKEVIWHGRT NDEPAHYCSI CEVEVFNLLF VTNESNTQKT YIVHCHDCAR KTSKSLENFV 1320
VLEQYKMEDL IQVYDQFTLA LSLSSSS 1348
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0903--Direct protein sequencing
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0862--Zinc
Interpro

IPR003347--JmjC_dom
IPR029516--KDM6C
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS51184--JMJC
PS50005--TPR
PS50293--TPR_REGION
Pfam

PF02373--JmjC
PF00515--TPR_1
PF13414--TPR_11
PF13181--TPR_8
Gene Ontology

GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0046872--F:metal ion binding
GO:0010468--P:regulation of gene expression