dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000697
Uniprot Accession O14604; TYB4Y_HUMAN; Q0VDA2;
Genbank Protein ID NP_004193.1;
Genbank Nucleotide ID NM_004202.2;
Protein Name Thymosin beta-4, Y-chromosomal
Protein Synonyms/Alias
Gene Name TMSB4Y
Gene Synonyms/Alias TB4Y;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
16EIEKFDKSKLKKTETPhosphoSitePlus;curated22135298; 26074081
21DKSKLKKTETQEKNPPhosphoSitePlus;curated22135298; 22817900; 26074081
23SKLKKTETQEKNPLSPhosphoSitePlus;curated22135298; 22817900; 26074081
Sequence
(Fasta)		MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES 45
Keyword

KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
Interpro

IPR001152--Beta-thymosin
PROSITE

PS00500--THYMOSIN_B4
Pfam

PF01290--Thymosin
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0007015--P:actin filament organization
GO:0001649--P:osteoblast differentiation
GO:0008064--P:regulation of actin polymerization or depolymerization
GO:0042989--P:sequestering of actin monomers