dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000693 |
| Uniprot Accession | O14595; CTDS2_HUMAN; A8K5H4; Q53ZR2; Q6NZY3; Q9UEX1; |
| Genbank Protein ID | NP_005721.3; |
| Genbank Nucleotide ID | NM_005730.3; |
| Protein Name | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 |
| Protein Synonyms/Alias | Nuclear LIM interactor-interacting factor 2;NLI-interacting factor 2;Protein OS-4;Small C-terminal domain phosphatase 2;Small CTD phosphatase 2;SCP2; |
| Gene Name | CTDSP2 |
| Gene Synonyms/Alias | NIF2;OS4;SCP2; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRNIFKA LFCCFRAQHV GQSSSSTELA 60 AYKEEANTIA KSDLLQCLQY QFYQIPGTCL LPEVTEEDQG RICVVIDLDE TLVHSSFKPI 120 NNADFIVPIE IEGTTHQVYV LKRPYVDEFL RRMGELFECV LFTASLAKYA DPVTDLLDRC 180 GVFRARLFRE SCVFHQGCYV KDLSRLGRDL RKTLILDNSP ASYIFHPENA VPVQSWFDDM 240 ADTELLNLIP IFEELSGAED VYTSLGQLRA P 272 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR011948--Dullard_phosphatase |
| PROSITE | PS50969--FCP1 |
| Pfam | PF03031--NIF |
| Gene Ontology | GO:0005654--C:nucleoplasm |