| Tag |
Content |
| dbPAF ID |
dbPAF-0000692 |
| Uniprot Accession |
O14594; NCAN_HUMAN; Q9UPK6;
|
| Genbank Protein ID |
NP_004377.2;
|
| Genbank Nucleotide ID |
NM_004386.2;
|
| Protein Name |
Neurocan core protein |
| Protein Synonyms/Alias |
Chondroitin sulfate proteoglycan 3; |
| Gene Name |
NCAN |
| Gene Synonyms/Alias |
CSPG3;NEUR; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.Functional Description
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MGAPFVWALG LLMLQMLLFV AGEQGTQDIT DASERGLHMQ KLGSGSVQAA LAELVALPCL 60
FTLQPRPSAA RDAPRIKWTK VRTASGQRQD LPILVAKDNV VRVAKSWQGR VSLPSYPRRR 120
ANATLLLGPL RASDSGLYRC QVVRGIEDEQ DLVPLEVTGV VFHYRSARDR YALTFAEAQE 180
ACRLSSAIIA APRHLQAAFE DGFDNCDAGW LSDRTVRYPI TQSRPGCYGD RSSLPGVRSY 240
GRRNPQELYD VYCFARELGG EVFYVGPARR LTLAGARAQC RRQGAALASV GQLHLAWHEG 300
LDQCDPGWLA DGSVRYPIQT PRRRCGGPAP GVRTVYRFAN RTGFPSPAER FDAYCFRAHH 360
PTSQHGDLET PSSGDEGEIL SAEGPPVREL EPTLEEEEVV TPDFQEPLVS SGEEETLILE 420
EKQESQQTLS PTPGDPMLAS WPTGEVWLST VAPSPSDMGA GTAASSHTEV APTDPMPRRR 480
GRFKGLNGRY FQQQEPEPGL QGGMEASAQP PTSEAAVNQM EPPLAMAVTE MLGSGQSRSP 540
WADLTNEVDM PGAGSAGGKS SPEPWLWPPT MVPPSISGHS RAPVLELEKA EGPSARPATP 600
DLFWSPLEAT VSAPSPAPWE AFPVATSPDL PMMAMLRGPK EWMLPHPTPI STEANRVEAH 660
GEATATAPPS PAAETKVYSL PLSLTPTGQG GEAMPTTPES PRADFRETGE TSPAQVNKAE 720
HSSSSPWPSV NRNVAVGFVP TETATEPTGL RGIPGSESGV FDTAESPTSG LQATVDEVQD 780
PWPSVYSKGL DASSPSAPLG SPGVFLVPKV TPNLEPWVAT DEGPTVNPMD STVTPAPSDA 840
SGIWEPGSQV FEEAESTTLS PQVALDTSIV TPLTTLEQGD KVGVPAMSTL GSSSSQPHPE 900
PEDQVETQGT SGASVPPHQS SPLGKPAVPP GTPTAASVGE SASVSSGEPT VPWDPSSTLL 960
PVTLGIEDFE LEVLAGSPGV ESFWEEVASG EEPALPGTPM NAGAEEVHSD PCENNPCLHG 1020
GTCNANGTMY GCSCDQGFAG ENCEIDIDDC LCSPCENGGT CIDEVNGFVC LCLPSYGGSF 1080
CEKDTEGCDR GWHKFQGHCY RYFAHRRAWE DAEKDCRRRS GHLTSVHSPE EHSFINSFGH 1140
ENTWIGLNDR IVERDFQWTD NTGLQFENWR ENQPDNFFAG GEDCVVMVAH ESGRWNDVPC 1200
NYNLPYVCKK GTVLCGPPPA VENASLIGAR KAKYNVHATV RYQCNEGFAQ HHVATIRCRS 1260
NGKWDRPQIV CTKPRRSHRM RRHHHHHQHH HQHHHHKSRK ERRKHKKHPT EDWEKDEGNF 1320
C
1322Fasta Sequence
>O14594|NCAN|Homo sapiens(Human)
MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNFC
|
| Keyword |
KW-0106--Calcium
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0373--Hyaluronic acid
KW-0393--Immunoglobulin domain
KW-0430--Lectin
KW-0621--Polymorphism
KW-0654--Proteoglycan
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0768--Sushi
|
| Interpro |
IPR001304--C-type_lectin
IPR016186--C-type_lectin-like
IPR018378--C-type_lectin_CS
IPR016187--C-type_lectin_fold
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR013106--Ig_V-set
IPR000538--Link_dom
IPR000436--Sushi_SCR_CCP_dom
|
| PROSITE |
PS00010--ASX_HYDROXYL
PS00615--C_TYPE_LECTIN_1
PS50041--C_TYPE_LECTIN_2
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS50835--IG_LIKE
PS01241--LINK_1
PS50963--LINK_2
PS50923--SUSHI
|
| Pfam |
PF00008--EGF
PF00059--Lectin_C
PF00084--Sushi
PF07686--V-set
PF00193--Xlink
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005796--C:Golgi lumen
GO:0043202--C:lysosomal lumen
GO:0005578--C:proteinaceous extracellular matrix
GO:0005509--F:calcium ion binding
GO:0030246--F:carbohydrate binding
GO:0005540--F:hyaluronic acid binding
GO:0007411--P:axon guidance
GO:0005975--P:carbohydrate metabolic process
GO:0007155--P:cell adhesion
GO:0007417--P:central nervous system development
GO:0030206--P:chondroitin sulfate biosynthetic process
GO:0030207--P:chondroitin sulfate catabolic process
GO:0030204--P:chondroitin sulfate metabolic process
GO:0030208--P:dermatan sulfate biosynthetic process
GO:0030198--P:extracellular matrix organization
GO:0030203--P:glycosaminoglycan metabolic process
GO:0001501--P:skeletal system development
GO:0044281--P:small molecule metabolic process
|
