dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000689
Uniprot Accession O14579; COPE_HUMAN; A6NE29; A6NKA3; O76097; Q6IBB8; Q9UGP6;
Genbank Protein ID NP_009194.2; NP_955474.1; NP_955476.1;
Genbank Nucleotide ID NM_007263.3; NM_199442.1; NM_199444.1;
Protein Name Coatomer subunit epsilon
Protein Synonyms/Alias Epsilon-coat protein;Epsilon-COP;
Gene Name COPE
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
10PPAPGPASGGSGEVDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18691976; 16381945; 23193290; 18988627; 22135298; 25627689;
13PGPASGGSGEVDELFdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20166139; 16381945; 23193290; 18669648; 18988627; 22135298;
44EAQRVKLSSPERDVEdbPTM 3.0;HPRD 9;curated18691976; 20068231; 16381945; 23193290; 18988627; 25627689;
45AQRVKLSSPERDVERdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 20363803; 18988627; 21081558;
95ADYLAHESRRDSIVAcurated25849741
99AHESRRDSIVAELDRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 18691976; 19690332; 16381945; 23193290; 20166139;
109AELDREMSRSVDVTNPHOSIDA21081558
202GEKLQDAYYIFQEMAPhosphoSitePlus;curated22135298; 22817900
260LVNLIVLSQHLGKPPPhosphoSitePlus22135298
283QLKDAHRSHPFIKEYPhosphoSitePlus22135298
307LVLQYAPSA------curated20873877
Sequence
(Fasta)		MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY 60
LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL 120
LMAASIYLHD QNPDAALRAL HQGDSLECTA MTVQILLKLD RLDLARKELK RMQDLDEDAT 180
LTQLATAWVS LATGGEKLQD AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ 240
EALDKDSGYP ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL 300
VLQYAPSA 309
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR006822--Coatomer_esu
IPR011990--TPR-like_helical_dom
PROSITE
Pfam

PF04733--Coatomer_E
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005198--F:structural molecule activity
GO:0048205--P:COPI coating of Golgi vesicle
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0061024--P:membrane organization
GO:0015031--P:protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER