dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000688
Uniprot Accession O14578; CTRO_HUMAN; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7;
Genbank Protein ID NP_001193928.1; NP_009105.1;
Genbank Nucleotide ID NM_001206999.1; NM_007174.2;
Protein Name Citron Rho-interacting kinase
Protein Synonyms/Alias
Gene Name CIT
Gene Synonyms/Alias CRIK;KIAA0949;STK21;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Phosphorylation Sites
 dbPAF PTMs: 59 (View all)
PositionPeptidesSourceReferences ( PMIDs )
232ENILVDRTGHIKLVDPhosphoSitePlus22135298
307RSPFAEGTSARTFNNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19691289; 16381945; 23193290; 18988627; 22135298
308SPFAEGTSARTFNNIPhosphoSitePlus22135298
371DWNNIRNSPPPFVPTPhosphoSitePlus;curated22135298; 25627689
398PEKNSWVSSSPCQLScurated25627689
431ALGILGRSESVVSGLPhosphoSitePlus;curated22135298; 25627689
433GILGRSESVVSGLDSdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 19691289; 18988627; 19060867;
436GRSESVVSGLDSPAKPhosphoSitePlus;curated22135298; 19690332; 20873877; 26074081
440SVVSGLDSPAKTSSMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16565220; 18669648; 18691976; 19007248; 19413330; 19690332;
445LDSPAKTSSMEKKLLcurated23836654
473HKMEQEMTRLHRRVSPHOSIDA21081558
480TRLHRRVSEVEAVLSPhosphoSitePlus;curated22135298; 25850435; 25627689; 23911959; 25849741; 24961811
582LVSARRRSDLYESELPhosphoSitePlus;curated22135298; 23186163; 20873877; 24961811
652LEKAVKASTEATELLdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
653EKAVKASTEATELLQdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
656VKASTEATELLQNIRdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
741KDLADKETLENMMQRdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298
772AMINAMDSKIRSLEQPhosphoSitePlus22135298
794ANKLAANSSLFTQRNPhosphoSitePlus22135298
841EEQLEKISHQDHSDKPhosphoSitePlus22135298
Sequence
(Fasta)		MLKFKYGARN PLDAGAAEPI ASRASRLNLF FQGKPPFMTQ QQMSPLSREG ILDALFVLFE 60
ECSQPALMKI KHVSNFVRKY SDTIAELQEL QPSAKDFEVR SLVGCGHFAE VQVVREKATG 120
DIYAMKVMKK KALLAQEQVS FFEEERNILS RSTSPWIPQL QYAFQDKNHL YLVMEYQPGG 180
DLLSLLNRYE DQLDENLIQF YLAELILAVH SVHLMGYVHR DIKPENILVD RTGHIKLVDF 240
GSAAKMNSNK MVNAKLPIGT PDYMAPEVLT VMNGDGKGTY GLDCDWWSVG VIAYEMIYGR 300
SPFAEGTSAR TFNNIMNFQR FLKFPDDPKV SSDFLDLIQS LLCGQKERLK FEGLCCHPFF 360
SKIDWNNIRN SPPPFVPTLK SDDDTSNFDE PEKNSWVSSS PCQLSPSGFS GEELPFVGFS 420
YSKALGILGR SESVVSGLDS PAKTSSMEKK LLIKSKELQD SQDKCHKMEQ EMTRLHRRVS 480
EVEAVLSQKE VELKASETQR SLLEQDLATY ITECSSLKRS LEQARMEVSQ EDDKALQLLH 540
DIREQSRKLQ EIKEQEYQAQ VEEMRLMMNQ LEEDLVSARR RSDLYESELR ESRLAAEEFK 600
RKATECQHKL LKAKDQGKPE VGEYAKLEKI NAEQQLKIQE LQEKLEKAVK ASTEATELLQ 660
NIRQAKERAE RELEKLQNRE DSSEGIRKKL VEAEELEEKH REAQVSAQHL EVHLKQKEQH 720
YEEKIKVLDN QIKKDLADKE TLENMMQRHE EEAHEKGKIL SEQKAMINAM DSKIRSLEQR 780
IVELSEANKL AANSSLFTQR NMKAQEEMIS ELRQQKFYLE TQAGKLEAQN RKLEEQLEKI 840
SHQDHSDKNR LLELETRLRE VSLEHEEQKL ELKRQLTELQ LSLQERESQL TALQAARAAL 900
ESQLRQAKTE LEETTAEAEE EIQALTAHRD EIQRKFDALR NSCTVITDLE EQLNQLTEDN 960
AELNNQNFYL SKQLDEASGA NDEIVQLRSE VDHLRREITE REMQLTSQKQ TMEALKTTCT 1020
MLEEQVMDLE ALNDELLEKE RQWEAWRSVL GDEKSQFECR VRELQRMLDT EKQSRARADQ 1080
RITESRQVVE LAVKEHKAEI LALQQALKEQ KLKAESLSDK LNDLEKKHAM LEMNARSLQQ 1140
KLETERELKQ RLLEEQAKLQ QQMDLQKNHI FRLTQGLQEA LDRADLLKTE RSDLEYQLEN 1200
IQVLYSHEKV KMEGTISQQT KLIDFLQAKM DQPAKKKKGL FSRRKEDPAL PTQVPLQYNE 1260
LKLALEKEKA RCAELEEALQ KTRIELRSAR EEAAHRKATD HPHPSTPATA RQQIAMSAIV 1320
RSPEHQPSAM SLLAPPSSRR KESSTPEEFS RRLKERMHHN IPHRFNVGLN MRATKCAVCL 1380
DTVHFGRQAS KCLECQVMCH PKCSTCLPAT CGLPAEYATH FTEAFCRDKM NSPGLQTKEP 1440
SSSLHLEGWM KVPRNNKRGQ QGWDRKYIVL EGSKVLIYDN EAREAGQRPV EEFELCLPDG 1500
DVSIHGAVGA SELANTAKAD VPYILKMESH PHTTCWPGRT LYLLAPSFPD KQRWVTALES 1560
VVAGGRVSRE KAEADAKLLG NSLLKLEGDD RLDMNCTLPF SDQVVLVGTE EGLYALNVLK 1620
NSLTHVPGIG AVFQIYIIKD LEKLLMIAGE ERALCLVDVK KVKQSLAQSH LPAQPDISPN 1680
IFEAVKGCHL FGAGKIENGL CICAAMPSKV VILRYNENLS KYCIRKEIET SEPCSCIHFT 1740
NYSILIGTNK FYEIDMKQYT LEEFLDKNDH SLAPAVFAAS SNSFPVSIVQ VNSAGQREEY 1800
LLCFHEFGVF VDSYGRRSRT DDLKWSRLPL AFAYREPYLF VTHFNSLEVI EIQARSSAGT 1860
PARAYLDIPN PRYLGPAISS GAIYLASSYQ DKLRVICCKG NLVKESGTEH HRGPSTSRSS 1920
PNKRGPPTYN EHITKRVASS PAPPEGPSHP REPSTPHRYR EGRTELRRDK SPGRPLEREK 1980
SPGRMLSTRR ERSPGRLFED SSRGRLPAGA VRTPLSQVNK VWDQSSV 2028
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0418--Kinase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0729--SH3-binding
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000961--AGC-kinase_C
IPR017405--Citron_Rho-interacting_kinase
IPR001180--CNH_dom
IPR011009--Kinase-like_dom
IPR002219--PE/DAG-bd
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS51285--AGC_KINASE_CTER
PS50219--CNH
PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00780--CNH
PF00169--PH
PF00069--Pkinase
PF00433--Pkinase_C
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0001726--C:ruffle
GO:0005773--C:vacuole
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0030165--F:PDZ domain binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0097110--F:scaffold protein binding
GO:0000910--P:cytokinesis
GO:0016358--P:dendrite development
GO:0048699--P:generation of neurons
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0000070--P:mitotic sister chromatid segregation
GO:0050774--P:negative regulation of dendrite morphogenesis
GO:0032467--P:positive regulation of cytokinesis
GO:0007264--P:small GTPase mediated signal transduction
GO:0007283--P:spermatogenesis