dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000687
Uniprot Accession O14576; DC1I1_HUMAN; B4DME3; F5H050; G5E9K1; Q8TBF7; Q9Y2X1;
Genbank Protein ID NP_001129028.1; NP_001129029.1; NP_001265350.1; NP_001265351.1; NP_004402.1; XP_011514163.1; XP_011514164.1;
Genbank Nucleotide ID NM_001135556.1; NM_001135557.1; NM_001278421.1; NM_001278422.1; NM_004411.4; XM_011515861.1; XM_011515862.1;
Protein Name Cytoplasmic dynein 1 intermediate chain 1
Protein Synonyms/Alias Cytoplasmic dynein intermediate chain 1;Dynein intermediate chain 1, cytosolic;DH IC-1;
Gene Name DYNC1I1
Gene Synonyms/Alias DNCI1;DNCIC1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
97YLVPTPMSPSSKSVSPhosphoSitePlus22135298
99VPTPMSPSSKSVSTPPhosphoSitePlus22135298
100PTPMSPSSKSVSTPSPhosphoSitePlus;curated22135298; 23663014
102PMSPSSKSVSTPSEAHPRD 9;PhosphoSitePlus;curated19413330; 20068231; 18988627; 22135298; 22817900
104SPSSKSVSTPSEAGSPhospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 19413330; 17287340; 20068231; 18988627; 22135298;
105PSSKSVSTPSEAGSQPhospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 19413330; 18491316; 18988627; 22135298; 19690332;
107SKSVSTPSEAGSQDSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated22067460; 16381945; 23193290; 18669648; 18988627; 22135298;
111STPSEAGSQDSGDLGPhosphoSitePlus;curated22135298; 22817900
114SEAGSQDSGDLGPLTPhosphoSitePlus22135298
165FLPREVVSYSKETQTPhosphoSitePlus22135298
172SYSKETQTPLATHQScurated24972180
176ETQTPLATHQSEEDEdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18510355; 16381945; 23193290; 18988627; 22135298; 19366988;
274VQAGANLSFNRQFYDPhosphoSitePlus22135298
635IRANRADSEEEGTVEdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 23911959; 22817900
Sequence
(Fasta)		MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 60
ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL 120
TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV SKVTQVDFLP REVVSYSKET QTPLATHQSE 180
EDEEDEEMVE SKVGQDSELE NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV 240
IERALAEDSD IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP 300
ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR FHPNLVVGGT 360
YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT QNAHNLITVS TDGKMCSWSL 420
DMLSTPQESM ELVYNKSKPV AVTGMAFPTG DVNNFVVGSE EGTVYTACRH GSKAGIGEVF 480
EGHQGPVTGI NCHMAVGPID FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW 540
SPVHPALFAC VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG 600
RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA 646
Keyword

KW-0025--Alternative splicing
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0243--Dynein
KW-0995--Kinetochore
KW-0493--Microtubule
KW-0505--Motor protein
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR025956--Dynein_IC_1/2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam

PF11540--Dynein_IC2
PF00400--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0005868--C:cytoplasmic dynein complex
GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0000922--C:spindle pole
GO:0031982--C:vesicle
GO:0008017--F:microtubule binding
GO:0003777--F:microtubule motor activity
GO:0003774--F:motor activity
GO:0030507--F:spectrin binding
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0047496--P:vesicle transport along microtubule