dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000683
Uniprot Accession O14559; RHG33_HUMAN; O14552; O14560; Q6ZSP6; Q96CP3; Q9NT23;
Genbank Protein ID NP_001166101.1; NP_443180.2; XP_005258545.1; XP_011524721.1;
Genbank Nucleotide ID NM_001172630.1; NM_052948.3; XM_005258488.1; XM_011526419.1;
Protein Name Rho GTPase-activating protein 33
Protein Synonyms/Alias Rho-type GTPase-activating protein 33;Sorting nexin-26;Tc10/CDC42 GTPase-activating protein;
Gene Name ARHGAP33
Gene Synonyms/Alias SNX26;TCGAP;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
178HGRRLLLSEEASLNIPhosphoSitePlus22135298
182LLLSEEASLNIPAVAPhosphoSitePlus22135298
406PLLTYQLYGKFSEAMdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated16777849; 16381945; 23193290; 18988627; 22135298; 22817900
442PHYRTLEYLLRHLARdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
552LEEAQARTQGRLGTPdbPTM 3.0;HPRD 9;PhosphoSitePlus18077418; 16381945; 23193290; 18988627; 22135298
558RTQGRLGTPTEPTTPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18077418; 16381945; 23193290; 18988627; 22135298; 22817900
560QGRLGTPTEPTTPKAdbPTM 3.0;HPRD 9;PhosphoSitePlus18077418; 16381945; 23193290; 18988627; 22135298
564GTPTEPTTPKAPASPPhosphoSitePlus;curated22135298; 23403867
624APPQPSGSRPDTVTLPhosphoSitePlus22135298
628PSGSRPDTVTLRSAKPhosphoSitePlus22135298
630GSRPDTVTLRSAKSEPhosphoSitePlus22135298
636VTLRSAKSEESLSSQdbPTM 3.0;PhosphoSitePlus;UniProt;curated21406692; 16381945; 23193290; 22135298; 22817900; 25849741
978PRQQSDGSLLRSQRPcurated22817900
1169PTPPEPLYVNLALGPPhosphoSitePlus22135298
Sequence
(Fasta)		MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG 60
HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS 120
CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE 180
ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS 240
ECVELFTERP GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ 300
RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR 360
LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGEEE 420
RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES 480
VGMGGAAAFR EVRVQSVVVE FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST 540
RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG 600
PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ RLHRLRRPHS 660
SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA AGLGALSGSP SHRTSAWLDD 720
GDELDFSPPR CLEGLRGLDF DPLTFRCSSP TPGDPAPPAS PAPPAPASAF PPRVTPQAIS 780
PRGPTSPASP AALDISEPLA VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL 840
LRGAEAPLTD ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM 900
ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG PPPNSLAHPG 960
AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS AQLRAGGGGR DAPEAAAQSP 1020
CSVPSQVPTP GFFSPAPREC LPPFLGVPKP GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD 1080
RGENLYYEIG ASEGSPYSGP TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP 1140
APSCFPPDHL GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG 1200
PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR GSLYRNGGQR 1260
GEGAGPPPPY PTPSWSLHSE GQTRSYC 1288
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0343--GTPase activation
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
Interpro

IPR001683--Phox
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain
PROSITE

PS50238--RHOGAP
PS50002--SH3
Pfam

PF00620--RhoGAP
PF14604--SH3_9
Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0035091--F:phosphatidylinositol binding
GO:0015031--P:protein transport
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction