dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000681
Uniprot Accession O14556; G3PT_HUMAN; B2RC82; O60823; Q6JTT9; Q9HCU6;
Genbank Protein ID NP_055179.1;
Genbank Nucleotide ID NM_014364.4;
Protein Name Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Protein Synonyms/Alias Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2;GAPDH-2;Spermatogenic glyceraldehyde-3-phosphate dehydrogenase;
Gene Name GAPDHS
Gene Synonyms/Alias GAPD2;GAPDH2;GAPDS;HSD-35;HSD35;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
77VSVARELTVGINGFGPhosphoSitePlus22135298
282HQNIIPASTGAAKAVcurated20068231; 22817900
283QNIIPASTGAAKAVTcurated20068231; 22817900
301PELKGKLTGMAFRVPPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 23911959
318DVSVVDLTCRLAQPAPhosphoPep 2.019060867
384DNFVKLISWYDNEYGcurated22817900
Sequence
(Fasta)		MSKRDIVLTN VTVVQLLRQP CPVTRAPPPP EPKAEVEPQP QPEPTPVREE IKPPPPPLPP 60
HPATPPPKMV SVARELTVGI NGFGRIGRLV LRACMEKGVK VVAVNDPFID PEYMVYMFKY 120
DSTHGRYKGS VEFRNGQLVV DNHEISVYQC KEPKQIPWRA VGSPYVVEST GVYLSIQAAS 180
DHISAGAQRV VISAPSPDAP MFVMGVNEND YNPGSMNIVS NASCTTNCLA PLAKVIHERF 240
GIVEGLMTTV HSYTATQKTV DGPSRKAWRD GRGAHQNIIP ASTGAAKAVT KVIPELKGKL 300
TGMAFRVPTP DVSVVDLTCR LAQPAPYSAI KEAVKAAAKG PMAGILAYTE DEVVSTDFLG 360
DTHSSIFDAK AGIALNDNFV KLISWYDNEY GYSHRVVDLL RYMFSRDK 409
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0324--Glycolysis
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR020831--GlycerAld/Erythrose_P_DH
IPR020830--GlycerAld_3-P_DH_AS
IPR020829--GlycerAld_3-P_DH_cat
IPR020828--GlycerAld_3-P_DH_NAD(P)-bd
IPR006424--Glyceraldehyde-3-P_DH_1
IPR016040--NAD(P)-bd_dom
PROSITE

PS00071--GAPDH
Pfam

PF02800--Gp_dh_C
PF00044--Gp_dh_N
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035686--C:sperm fibrous sheath
GO:0097228--C:sperm principal piece
GO:0004365--F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0051287--F:NAD binding
GO:0050661--F:NADP binding
GO:0061621--P:canonical glycolysis
GO:0005975--P:carbohydrate metabolic process
GO:0006094--P:gluconeogenesis
GO:0006006--P:glucose metabolic process
GO:0045821--P:positive regulation of glycolytic process
GO:0044281--P:small molecule metabolic process
GO:0030317--P:sperm motility
GO:0007286--P:spermatid development