dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000679
Uniprot Accession O14545; TRAD1_HUMAN; A8K5L6; B4DI89;
Genbank Protein ID NP_001137378.1; NP_006691.1;
Genbank Nucleotide ID NM_001143906.1; NM_006700.2;
Protein Name TRAF-type zinc finger domain-containing protein 1
Protein Synonyms/Alias Protein FLN29;
Gene Name TRAFD1
Gene Synonyms/Alias FLN29;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 35 (View all)
PositionPeptidesSourceReferences ( PMIDs )
98QHCDLELSILKLKEHPhosphoSitePlus;curated22135298; 25627689
108KLKEHEDYCGARTELPhosphoSitePlus22135298
191RPLRAFESDVFHNRTPhosphoSitePlus;curated22135298; 20873877; 23186163
209RNITAQVSIQNNLFEPhosphoSitePlus22135298
272AVCEADQSHGGPRSLPhosphoSitePlus;curated22135298; 25627689
278QSHGGPRSLSDIKGAPhosphoSitePlus;curated22135298; 25627689; 23917254; 22798277; 24961811
280HGGPRSLSDIKGAADcurated25627689; 23898821
320NPSRALPSLNTGSSSdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18212344; 16381945; 23193290; 18988627; 22135298; 19366988;
323RALPSLNTGSSSPRGdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18187866; 19369195; 16381945; 23193290; 19415658; 19664995;
325LPSLNTGSSSPRGVEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19415658; 19664995; 20058876; 16381945; 23193290; 19651622;
326PSLNTGSSSPRGVEEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 19664995; 20815410; 21406692;
327SLNTGSSSPRGVEEPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 18187866; 18669648; 18691976; 19369195; 19413330;
409EGIPRLDSQPQETSPdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
414LDSQPQETSPELPRRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18187866; 16381945; 23193290; 18669648; 19664995; 20058876;
415DSQPQETSPELPRRRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16565220; 16964243; 17081983; 17287340; 18187866; 18669648;
430VRHQGDLSSGYLDDTPhosphoSitePlus;curated22135298; 25627689; 23898821
431RHQGDLSSGYLDDTKcurated25627689
433QGDLSSGYLDDTKQEPhosphoSitePlus;curated22135298; 25627689
468TYNQLSRSTSGPRPGcurated25627689; 25262027
469YNQLSRSTSGPRPGCcurated25627689
Sequence
(Fasta)		MAEFLDDQET RLCDNCKKEI PVFNFTIHEI HCQRNIGMCP TCKEPFPKSD METHMAAEHC 60
QVTCKCNKKL EKRLLKKHEE TECPLRLAVC QHCDLELSIL KLKEHEDYCG ARTELCGNCG 120
RNVLVKDLKT HPEVCGREGE EKRNEVAIPP NAYDESWGQD GIWIASQLLR QIEALDPPMR 180
LPRRPLRAFE SDVFHNRTTN QRNITAQVSI QNNLFEEQER QERNRGQQPP KEGGEESANL 240
DFMLALSLQN EGQASSVAEQ DFWRAVCEAD QSHGGPRSLS DIKGAADEIM LPCEFCEELY 300
PEELLIDHQT SCNPSRALPS LNTGSSSPRG VEEPDVIFQN FLQQAASNQL DSLMGLSNSH 360
PVEESIIIPC EFCGVQLEEE VLFHHQDQCD QRPATATNHV TEGIPRLDSQ PQETSPELPR 420
RRVRHQGDLS SGYLDDTKQE TANGPTSCLP PSRPINNMTA TYNQLSRSTS GPRPGCQPSS 480
PCVPKLSNSD SQDIQGRNRD SQNGAIAPGH VSVIRPPQNL YPENIVPSFS PGPSGRYGAS 540
GRSEGGRNSR VTPAAANYRS RTAKAKPSKQ QGAGDAEEEE EE 583
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015880--Znf_C2H2-like
PROSITE
Pfam
Gene Ontology

GO:0046872--F:metal ion binding
GO:0045824--P:negative regulation of innate immune response