dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000678
Uniprot Accession O14544; SOCS6_HUMAN; Q8WUM3;
Genbank Protein ID NP_004223.2; XP_005266840.1;
Genbank Nucleotide ID NM_004232.3; XM_005266783.2;
Protein Name Suppressor of cytokine signaling 6
Protein Synonyms/Alias
Gene Name SOCS6
Gene Synonyms/Alias CIS4;SOCS4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
12SLKTLRKSFNLNKSKPhosphoSitePlus;curated22135298; 23186163
18KSFNLNKSKEETDFMcurated23090842
70GGKNRSKSESLMGTLPhosphoSitePlus;curated22135298; 25627689; 23090842
72KNRSKSESLMGTLKRcurated25627689
93KSKGKAGTPSGSSADcurated25627689
132TSLRSHHYSPAPWPLPhosphoSitePlus22135298
142APWPLRPTNSEETCIPhosphoSitePlus22135298
144WPLRPTNSEETCIKMPhosphoSitePlus22135298
147RPTNSEETCIKMEVRPhosphoSitePlus22135298
162VKALVHSSSPSPALNcurated25627689
163KALVHSSSPSPALNGPhosphoSitePlus;curated22135298; 25627689
165LVHSSSPSPALNGVRcurated25849741
220IGLMPQDYIQYTVPLPhosphoSitePlus22135298
223MPQDYIQYTVPLDEGPhosphoSitePlus22135298
311HDDVPPLSPLLPPMQPhosphoSitePlus;curated22135298; 25850435
358APGVARVYDSVQSSGPhosphoSitePlus22135298
405LANVPDGSFLVRDSSPhosphoSitePlus22135298
416RDSSDDRYLLSLSFRPhosphoSitePlus22135298
419SDDRYLLSLSFRSHGdbPTM 3.0;PhosphoSitePlus;curated18187866; 16381945; 23193290; 22135298; 22817900
443SNGRFSFYEQPDVEGPhosphoSitePlus22135298
Sequence
(Fasta)		MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED 60
EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR 120
PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS 180
ETTCQEQANS LKSSASHNGD LHLHLDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY 240
CLDSSSPMEV SAVPPQVGGR AFPEDESQVD QDLVVAPEIF VDQSVNGLLI GTTGVMLQSP 300
RAGHDDVPPL SPLLPPMQNN QIQRNFSGLT GTEAHVAESM RCHLNFDPNS APGVARVYDS 360
VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL 420
SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS 480
ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY 536
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0006952--P:defense response
GO:0007259--P:JAK-STAT cascade
GO:1904030--P:negative regulation of cyclin-dependent protein kinase activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth