dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000677
Uniprot Accession O14543; SOCS3_HUMAN; O14509;
Genbank Protein ID NP_003946.3;
Genbank Nucleotide ID NM_003955.4;
Protein Name Suppressor of cytokine signaling 3
Protein Synonyms/Alias
Gene Name SOCS3
Gene Synonyms/Alias CIS3;SSI3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
86FFTLSVKTQSGTKNLPhosphoSitePlus22135298
165GSPPRRAYYIYSGGEPhosphoSitePlus22135298
166SPPRRAYYIYSGGEKPhosphoSitePlus22135298
204VNGHLDSYEKVTQLPdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;curated12783885; 16381945; 23193290; 15173187; 16352613; 18083107;
221IREFLDQYDAPL---dbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus12783885; 15173187; 16381945; 23193290; 16352613; 22135298
Sequence
(Fasta)		MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120
LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR 180
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL 226
Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0582--Pharmaceutical
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004860--F:protein kinase inhibitor activity
GO:0007568--P:aging
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0060397--P:JAK-STAT cascade involved in growth hormone signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:1904030--P:negative regulation of cyclin-dependent protein kinase activity
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0031100--P:organ regeneration
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway
GO:0060338--P:regulation of type I interferon-mediated signaling pathway
GO:0042493--P:response to drug
GO:0032355--P:response to estradiol
GO:0032094--P:response to food
GO:0010332--P:response to gamma radiation
GO:0051384--P:response to glucocorticoid
GO:0009408--P:response to heat
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032496--P:response to lipopolysaccharide
GO:0032570--P:response to progesterone
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation
GO:0060337--P:type I interferon signaling pathway