dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000676
Uniprot Accession O14531; DPYL4_HUMAN; B2RMQ1; D3DRG5; O00240; Q5T0Q7;
Genbank Protein ID NP_006417.2;
Genbank Nucleotide ID NM_006426.2;
Protein Name Dihydropyrimidinase-related protein 4
Protein Synonyms/Alias
Gene Name DPYSL4
Gene Synonyms/Alias CRMP3;ULIP4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
292TDGSHYWSKNWAKAAPhosphoSitePlus22135298
537PVRNLHQSGFSLSGScurated20068231; 22817900
544SGFSLSGSQADDHIAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18988627; 19060867; 22135298;
Sequence
(Fasta)
MSFQGKKSIP RITSDRLLIR GGRIVNDDQS FYADVHVEDG LIKQIGENLI VPGGIKTIDA 60
HGLMVLPGGV DVHTRLQMPV LGMTPADDFC QGTKAALAGG TTMILDHVFP DTGVSLLAAY 120
EQWRERADSA ACCDYSLHVD ITRWHESIKE ELEALVKEKG VNSFLVFMAY KDRCQCSDSQ 180
MYEIFSIIRD LGALAQVHAE NGDIVEEEQK RLLELGITGP EGHVLSHPEE VEAEAVYRAV 240
TIAKQANCPL YVTKVMSKGA ADAIAQAKRR GVVVFGEPIT ASLGTDGSHY WSKNWAKAAA 300
FVTSPPVNPD PTTADHLTCL LSSGDLQVTG SAHCTFTTAQ KAVGKDNFAL IPEGTNGIEE 360
RMSMVWEKCV ASGKMDENEF VAVTSTNAAK IFNFYPRKGR VAVGSDADLV IWNPKATKII 420
SAKTHNLNVE YNIFEGVECR GAPAVVISQG RVALEDGKMF VTPGAGRFVP RKTFPDFVYK 480
RIKARNRLAE IHGVPRGLYD GPVHEVMVPA KPGSGAPARA SCPGKISVPP VRNLHQSGFS 540
LSGSQADDHI ARRTAQKIMA PPGGRSNITS LS 573
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR006680--Amidohydro-rel
IPR030612--DRP4
IPR011778--Hydantoinase/dihydroPyrase
IPR011059--Metal-dep_hydrolase_composite
IPR032466--Metal_Hydrolase

PROSITE
Pfam

PF01979--Amidohydro_1

Gene Ontology

GO:0005829--C:cytosol
GO:0016810--F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0007411--P:axon guidance
GO:0007399--P:nervous system development
GO:0070997--P:neuron death