dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000675
Uniprot Accession O14530; TXND9_HUMAN; B2R9G8; D3DVI4; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6;
Genbank Protein ID NP_005774.2;
Genbank Nucleotide ID NM_005783.3;
Protein Name Thioredoxin domain-containing protein 9
Protein Synonyms/Alias ATP-binding protein associated with cell differentiation;Protein 1-4;
Gene Name TXNDC9
Gene Synonyms/Alias APACD;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
145LHIKVIPTLALLKDGdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
181TLEWRLGSSDILNYScurated20873877
182LEWRLGSSDILNYSGcurated20873877
187GSSDILNYSGNLMEPdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558; 22199227;
188SSDILNYSGNLMEPPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 20068231; 18988627;
221IRGKKYDSDSDDD--dbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated21406692; 22115753; 16381945; 23193290; 19651622; 18988627;
223GKKYDSDSDDD----dbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated21406692; 22115753; 16381945; 23193290; 19651622; 18988627;
Sequence
(Fasta)		MEADASVDMF SKVLEHQLLQ TTKLVEEHLD SEIQKLDQMD EDELERLKEK RLQALRKAQQ 60
QKQEWLSKGH GEYREIPSER DFFQEVKESE NVVCHFYRDS TFRCKILDRH LAILSKKHLE 120
TKFLKLNVEK APFLCERLHI KVIPTLALLK DGKTQDYVVG FTDLGNTDDF TTETLEWRLG 180
SSDILNYSGN LMEPPFQNQK KFGTNFTKLE KKTIRGKKYD SDSDDD 227
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR012336--Thioredoxin-like_fold
IPR013766--Thioredoxin_domain
PROSITE
Pfam

PF00085--Thioredoxin
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0030496--C:midbody
GO:0005634--C:nucleus
GO:0045454--P:cell redox homeostasis