dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000674
Uniprot Accession O14529; CUX2_HUMAN; A7E2Y4;
Genbank Protein ID NP_056082.2;
Genbank Nucleotide ID NM_015267.3;
Protein Name Homeobox protein cut-like 2
Protein Synonyms/Alias Homeobox protein cux-2;
Gene Name CUX2
Gene Synonyms/Alias CUTL2;KIAA0293;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
26RLQKELNSVASELSAdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
29KELNSVASELSARQEcurated20068231
79QAEVVALSKRSQEAEPHOSIDA21081558
143KRNPELLSPKEQREGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt18669648; 16381945; 23193290; 18988627; 22135298; 19366988
151PKEQREGTSPAGPTLdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558; 22817900;
152KEQREGTSPAGPTLTdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 21406692; 16381945; 23193290; 18988627; 21081558;
157GTSPAGPTLTEGSRLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated21406692; 16381945; 23193290; 20068231; 18988627; 21081558;
159SPAGPTLTEGSRLPGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.018669648; 16381945; 23193290; 18988627; 22135298; 19366988
162GPTLTEGSRLPGIPGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.018669648; 16381945; 23193290; 18988627; 22135298; 19366988
370EEIKTELSILKAMKLPhosphoSitePlus22135298
587VLGLSQGSVSEILARPhosphoSitePlus22135298
635IQVRQRGSITPRIRTdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
642SITPRIRTPETGSDDdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
645PRIRTPETGSDDAIKdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
647IRTPETGSDDAIKSIdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
672QKGGEPKTSVAPLSIPhosphoSitePlus22135298
673KGGEPKTSVAPLSIAPhosphoSitePlus22135298
927GEKVLGLSQGSVSDMHPRD 9;PhosphoSitePlus;curated20068231; 18988627; 22135298; 25850435; 25627689
936GSVSDMLSRPKPWSKPHOSIDA;curated21081558; 20068231
974VGQQPGASQASPTEPPHOSIDA21081558
Sequence
(Fasta)		MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR EFKKNVPEEI 60
REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP DPVPVFEAAR SLDDRLQPPS 120
FDPSGQPRRD LHTSWKRNPE LLSPKEQREG TSPAGPTLTE GSRLPGIPGK ALLTETLLQR 180
NEAEKQKGLQ EVQITLAARL GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG 240
LIMTNLEKAN QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE 300
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE KLEEKLQAQS 360
DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE AFFPTQKFLL EKPSLLASPE 420
EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP 480
FPSLASGERL MMPPAAFKGE AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG 540
GGAAGPGAEE EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK 600
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA IKSILEQAKK 660
EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA RREMQAQQQA LLEMEVAPRG 720
RSVPPSPPER PSLATASQNG APALVKQEEG SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG 780
DAGYFDHHWA SDRGLLSRPY ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA 840
GAEDEPPRTG ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE 900
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE PFIRMQLWLS 960
DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE PLSLSLESSK ENQQPEGRSS 1020
SSLSGKMYSG SQAPGGIQEI VAMSPELDTY SITKRVKEVL TDNNLGQRLF GESILGLTQG 1080
SVSDLLSRPK PWHKLSLKGR EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST 1140
GSDSESPATR SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL 1200
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG HSHPDPTPQS 1260
PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ EQMEEDAEEE AGSQPQDSGE 1320
LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL PGGSTPDCPS LHPQQESEAG ERLHPDPLSF 1380
KSASESSRCS LEVSLNSPSA ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD 1440
MAGALHPSAK VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF 1487
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR003350--CUT_dom
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
IPR010982--Lambda_DNA-bd_dom
PROSITE

PS51042--CUT
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
Pfam

PF02376--CUT
PF00046--Homeobox
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0071310--P:cellular response to organic substance
GO:0050890--P:cognition
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:2000463--P:positive regulation of excitatory postsynaptic potential
GO:0010628--P:positive regulation of gene expression
GO:0051965--P:positive regulation of synapse assembly
GO:0007614--P:short-term memory
GO:0006351--P:transcription, DNA-templated