dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000673
Uniprot Accession O14526; FCHO1_HUMAN; A6NHE6; A8K5U5; B4E120; Q05C93; Q8IW22;
Genbank Protein ID NP_001154829.1; NP_001154830.1; NP_001154831.1; NP_055937.1; XP_006722764.1; XP_006722765.1; XP_011526126.1; XP_011526127.1; XP_011526128.1; XP_011526130.1;
Genbank Nucleotide ID NM_001161357.1; NM_001161358.1; NM_001161359.1; NM_015122.2; XM_006722701.2; XM_006722702.2; XM_011527824.1; XM_011527825.1; XM_011527826.1; XM_011527828.1;
Protein Name F-BAR domain only protein 1
Protein Synonyms/Alias
Gene Name FCHO1
Gene Synonyms/Alias KIAA0290;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
Phosphorylation Sites
 dbPAF PTMs: 30 (View all)
PositionPeptidesSourceReferences ( PMIDs )
20NHGFEVLYHSVKQGPPhosphoSitePlus22135298
30VKQGPISTKELADFIPhosphoSitePlus22135298
141LPKSRENYLNRCMDQdbPTM 3.0;HPRD 9;PhosphoSitePlus19664994; 16381945; 23193290; 18988627; 22135298
155QERLRRESTSQKEMDPhosphoSitePlus22135298
295AFRLPGLSRREREPEPhosphoSitePlus;curated22135298; 23917254; 25003641
344AEPSRFSSSDSDFDDcurated25262027
347SRFSSSDSDFDDEEPPhosphoSitePlus;curated22135298; 23917254
358DEEPRKFYVHIKPAPPhosphoSitePlus22135298
372PARAPACSPEAAAAQPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 23917254; 26074081; 25262027
386QLRATAGSLILPPGPPhosphoSitePlus22135298
396LPPGPGGTMKRHSSRPhosphoSitePlus22135298
420RSAPRTSSCAERLQSPhosphoSitePlus22135298
427SCAERLQSEEQVSKNPhosphoSitePlus;curated22135298; 25262027
479VEDSGLDSPSHAAPGcurated26074081
498SWVPRPGTPQSPPSCcurated26074081
501PRPGTPQSPPSCRAPcurated23917254; 26074081
523RAPPLPDSPQPLASSPhosphoSitePlus;curated22135298; 26074081
529DSPQPLASSPGPWGLPhosphoSitePlus22135298
530SPQPLASSPGPWGLEPhosphoSitePlus;curated22135298; 26074081
570RLRSRKVSCPLTRSNPhosphoSitePlus;curated22135298; 23917254; 22798277
Sequence
(Fasta)		MSYFGEHFWG EKNHGFEVLY HSVKQGPIST KELADFIRER ATIEETYSKA MAKLSKLASN 60
GTPMGTFAPL WEVFRVSSDK LALCHLELTR KLQDLIKDVL RYGEEQLKTH KKCKEEVVST 120
LDAVQVLSGV SQLLPKSREN YLNRCMDQER LRRESTSQKE MDKAETKTKK AAESLRRSVE 180
KYNSARADFE QKMLDSALRF QAMEETHLRH MKALLGSYAH SVEDTHVQIG QVHEEFKQNI 240
ENVSVEMLLR KFAESKGTGR EKPGPLDFEA YSAAALQEAM KRLRGAKAFR LPGLSRRERE 300
PEPPAAVDFL EPDSGTCPEV DEEGFTVRPD VTQNSTAEPS RFSSSDSDFD DEEPRKFYVH 360
IKPAPARAPA CSPEAAAAQL RATAGSLILP PGPGGTMKRH SSRDAAGKPQ RPRSAPRTSS 420
CAERLQSEEQ VSKNLFGPPL ESAFDHEDFT GSSSLGFTSS PSPFSSSSPE NVEDSGLDSP 480
SHAAPGPSPD SWVPRPGTPQ SPPSCRAPPP EARGIRAPPL PDSPQPLASS PGPWGLEALA 540
GGDLMPAPAD PTAREGLAAP PRRLRSRKVS CPLTRSNGDL SRSLSPSPLG SSAASTALER 600
PSFLSQTGHG VSRGPSPVVL GSQDALPIAT AFTEYVHAYF RGHSPSCLAR VTGELTMTFP 660
AGIVRVFSGT PPPPVLSFRL VHTTAIEHFQ PNADLLFSDP SQSDPETKDF WLNMAALTEA 720
LQRQAEQNPT ASYYNVVLLR YQFSRPGPQS VPLQLSAHWQ CGATLTQVSV EYGYRPGATA 780
VPTPLTNVQI LLPVGEPVTN VRLQPAATWN LEEKRLTWRL PDVSEAGGSG RLSASWEPLS 840
GPSTPSPVAA QFTSEGTTLS GVDLELVGSG YRMSLVKRRF ATGMYLVSC
Keyword

KW-0025--Alternative splicing
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR030121--FCHo1
IPR028565--MHD
IPR018808--Muniscin_C
PROSITE

PS51741--F_BAR
PS51072--MHD
Pfam

PF00611--FCH
PF10291--muHD
Gene Ontology

GO:0005905--C:coated pit
GO:0005886--C:plasma membrane
GO:0035612--F:AP-2 adaptor complex binding
GO:0048268--P:clathrin coat assembly
GO:0072583--P:clathrin-mediated endocytosis