dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000672
Uniprot Accession O14525; ASTN1_HUMAN; A5PL12; B4DHI9; E9PFR8; O60799; Q5W0V7; Q5W0V8;
Genbank Protein ID NP_996991.1;
Genbank Nucleotide ID NM_207108.2;
Protein Name Astrotactin-1
Protein Synonyms/Alias
Gene Name ASTN1
Gene Synonyms/Alias ASTN;KIAA0289;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
351NPEGDSGTEAENDPQPhosphoPep 2.019060867
1095SFVDDIISGAKSPCAPhosphoSitePlus22135298
1258LRRSSLKYLGCRYSEPhosphoSitePlus22135298
1263LKYLGCRYSEIKPYGPhosphoSitePlus22135298
1277GLDWAELSRDLRKTCdbPTM 3.0;PhosphoSitePlus;curated18187866; 16381945; 23193290; 22135298; 24260401
Sequence
(Fasta)
MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE NDLSIMHSPS 60
ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT EDIPLVRWRQ QWLENGTLLF 120
HIHHQDGAPS LPGQDPTEEP QHESAEEELR ILHISVMGGM IALLLSILCL VMILYTRRRW 180
CKRRRVPQPQ KSASAEAANE IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD 240
GYEYDITDLR HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK 300
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG TEAENDPQLT 360
FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC SSHVNCPLVV KITLHVPEHL 420
IADGSRFILL EGSQLDASDW LNPAQVVLFS QQNSSGPWAM DLCARRLLDP CEHQCDPETG 480
RREHRAAGEC LCYEGYMKDP VHKHLCIRNE WGTNQGPWPY TIFQRGFDLV LGEQPSDKIF 540
RFTYTLGEGM WLPLSKSFVI PPAELAINPS AKCKTDMTVM EDAVEVREEL MTSSSFDSLE 600
VLLDSFGPVR DCSKDNGGCS KNFRCISDRK LDSTGCVCPS GLSPMKDSSG CYDRHIGVDC 660
SDGFNGGCEQ LCLQQMAPFP DDPTLYNILM FCGCIEDYKL GVDGRSCQLI TETCPEGSDC 720
GESRELPMNQ TLFGEMFFGY NNHSKEVAAG QVLKGTFRQN NFARGLDQQL PDGLVVATVP 780
LENQCLEEIS EPTPDPDFLT GMVNFSEVSG YPVLQHWKVR SVMYHIKLNQ VAISQALSNA 840
LHSLDGATSR ADFVALLDQF GNHYIQEAIY GFEESCSIWY PNKQVQRRLW LEYEDISKGN 900
SPSDESEERE RDPKVLTFPE YITSLSDSGT KHMAAGVRME CHSKGRCPSS CPLCHVTSSP 960
DTPAEPVLLE VTKAAPIYEL VTNNQTQRLL QEATMSSLWC SGTGDVIEDW CRCDSTAFGA 1020
DGLPTCAPLP QPVLRLSTVH EPSSTLVVLE WEHSEPPIGV QIVDYLLRQE KVTDRMDHSK 1080
VETETVLSFV DDIISGAKSP CAMPSQVPDK QLTTISLIIR CLEPDTIYMF TLWGVDNTGR 1140
RSRPSDVIVK TPCPVVDDVK AQEIADKIYN LFNGYTSGKE QQTAYNTLLD LGSPTLHRVL 1200
YHYNQHYESF GEFTWRCEDE LGPRKAGLIL SQLGDLSSWC NGLLQEPKIS LRRSSLKYLG 1260
CRYSEIKPYG LDWAELSRDL RKTCEEQTLS IPYNDYGDSK EI 1303
Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR026995--Astrotactin
IPR000742--EGF-like_dom
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR020864--MACPF

PROSITE
Pfam
Gene Ontology

GO:0005768--C:endosome
GO:0009897--C:external side of plasma membrane
GO:0016021--C:integral component of membrane
GO:0007626--P:locomotory behavior
GO:0007158--P:neuron cell-cell adhesion
GO:0001764--P:neuron migration