dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000669
Uniprot Accession O14522; PTPRT_HUMAN; A8E4R6; O43655; O75664; Q5W0X9; Q5W0Y1; Q9BR24; Q9BR28; Q9H0Y8; Q9NTL1; Q9NU72; Q9UBD2; Q9UJL7;
Genbank Protein ID NP_008981.4; NP_573400.3;
Genbank Nucleotide ID NM_007050.5; NM_133170.3;
Protein Name Receptor-type tyrosine-protein phosphatase T
Protein Synonyms/Alias
Gene Name PTPRT
Gene Synonyms/Alias KIAA0283;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in both signal transduction and cellular adhesion in the CNS.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
100PTLKENDTHCIDFHYcurated24260401
107THCIDFHYYFSSRDRPhosphoSitePlus;curated22135298; 24260401
108HCIDFHYYFSSRDRSPhosphoSitePlus;curated22135298; 24260401
110IDFHYYFSSRDRSSPPhosphoSitePlus22135298
111DFHYYFSSRDRSSPGPhosphoSitePlus22135298
240RDTALMVTRVVNHRRPhosphoSitePlus22135298
249VVNHRRFSATVSVADPhosphoSitePlus22135298
251NHRRFSATVSVADTAPhosphoSitePlus22135298
253RRFSATVSVADTAQRPhosphoSitePlus22135298
404DIRARQLTLQWEPFGPhosphoSitePlus22135298
412LQWEPFGYAVTRCHSPhosphoSitePlus22135298
415EPFGYAVTRCHSYNLPhosphoSitePlus22135298
536LDPSADLSSQRGKVFPhosphoSitePlus22135298
537DPSADLSSQRGKVFKPhosphoSitePlus22135298
728RLATKGASTQNSNTVPhosphoSitePlus22135298
744PEKQVDNTVKMAGVIPhosphoSitePlus22135298
767ILLGVMLTIKRRRNAPhosphoSitePlus22135298
893GYGFKEEYEALPEGQPhosphoSitePlus22135298
918ENRNKNRYGNIISYDPhosphoSitePlus22135298
924RYGNIISYDHSRVRLPhosphoSitePlus22135298
Sequence
(Fasta)		MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN GFTWEQINTW 60
EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYFS SRDRSSPGAL 120
NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD 180
EVRVLAHPCR KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT 240
RVVNHRRFSA TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 300
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL DPDVEYEIRV 360
LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA RQLTLQWEPF GYAVTRCHSY 420
NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR GLRPFMTIRL RLLLSNPEGR MESEELVVQT 480
EEDVPGAVPL ESIQGGPFEE KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG 540
KVFKLRNETH HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 600
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV SYRNASSLDS 660
LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS YSIYFQALSK ANGETKINCV 720
RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV IAGLLMFIII LLGVMLTIKR RRNAYSYSYY 780
LKLAKKQKET QSGAQREMGP VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ 840
PTLTIQTHPY RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ 900
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG YHRPRHYIAT 960
QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY WPDDTEVYGD IKVTLIETEP 1020
LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI 1080
VVHCSAGAGR TGCFIAIDTM LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI 1140
LEACLCGNTA IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP 1200
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ HPLPNTVADF 1260
WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ VEFVSADIDE DIIHRIFRIC 1320
NMARPQDGYR IVQHLQYIGW PAYRDTPPSK RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN 1380
GGGRSGTFCA ICSVCEMIQQ QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS 1440
F 1442
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013320--ConA-like_dom
IPR003961--FN3_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR000998--MAM_dom
IPR029021--Prot-tyrosine_phosphatase-like
IPR000242--PTPase_domain
IPR016130--Tyr_Pase_AS
IPR000387--TYR_PHOSPHATASE_dom
PROSITE

PS50853--FN3
PS50835--IG_LIKE
PS00740--MAM_1
PS50060--MAM_2
PS00383--TYR_PHOSPHATASE_1
PS50056--TYR_PHOSPHATASE_2
PS50055--TYR_PHOSPHATASE_PTP
Pfam

PF00041--fn3
PF00629--MAM
PF00102--Y_phosphatase
Gene Ontology

GO:0009986--C:cell surface
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0045294--F:alpha-catenin binding
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0070097--F:delta-catenin binding
GO:0045295--F:gamma-catenin binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0007155--P:cell adhesion
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0006470--P:protein dephosphorylation
GO:0007165--P:signal transduction
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway