dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000666
Uniprot Accession O14514; BAI1_HUMAN;
Genbank Protein ID NP_001693.2; XP_011515501.1;
Genbank Nucleotide ID NM_001702.2; XM_011517199.1;
Protein Name Brain-specific angiogenesis inhibitor 1
Protein Synonyms/Alias
Gene Name BAI1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
66AVFPANASRCSWTLRPhosphoSitePlus22135298
287GLQTRTRTCLPAPGVPhosphoSitePlus22135298
330RSQSLRSTDARRREEPhosphoSitePlus22135298
537SWGSCSVTCGAGSQRPhosphoSitePlus22135298
609VRCPRNATGLILRRCPhosphoSitePlus;curated22135298; 23186163
1257TGTLKRPSLPEEEKLPhosphoSitePlus;curated22135298; 25850435
1278GPPTNFNSLPANVSKcurated25850435
1306LPDFPNHSLTLKRDKcurated25850435
1308DFPNHSLTLKRDKAPcurated25850435
1350TSYVILPTATATLRPPhosphoSitePlus22135298
1469VATLSVSSLERRKSRdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 25850435
1554ELEPLQPSPLELRSVcurated25850435
Sequence
(Fasta)		MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK FFGYFSAAAV 60
FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR TYQFDSFLES TRTYLGVESF 120
DEVLRLCDPS APLAFLQASK QFLQMRRQQP PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN 180
PSRAACQMLC RWLDACLAGS RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV 240
AGGPENCLTS LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE 300
GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP QTGDPAAEEW 360
SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC NNSAVCPVHG AWDEWSPWSL 420
CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE KQTKFCNIAL CPGRAVDGNW NEWSSWSACS 480
ASCSQGRQQR TRECNGPSYG GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGA 540
GSQRRERVCS GPFFGGAACQ GPQDEYRQCG TQRCPEPHEI CDEDNFGAVI WKETPAGEVA 600
AVRCPRNATG LILRRCELDE EGIAYWEPPT YIRCVSIDYR NIQMMTREHL AKAQRGLPGE 660
GVSEVIQTLV EISQDGTSYS GDLLSTIDVL RNMTEIFRRA YYSPTPGDVQ NFVQILSNLL 720
AEENRDKWEE AQLAGPNAKE LFRLVEDFVD VIGFRMKDLR DAYQVTDNLV LSIHKLPASG 780
ATDISFPMKG WRATGDWAKV PEDRVTVSKS VFSTGLTEAD EASVFVVGTV LYRNLGSFLA 840
LQRNTTVLNS KVISVTVKPP PRSLRTPLEI EFAHMYNGTT NQTCILWDET DVPSSSAPPQ 900
LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAN MEKATLPSVT LIVGCGVSSL 960
TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI GQTQTRNKVV CTLVAAFLHF 1020
FFLSSFCWVL TEAWQSYMAV TGHLRNRLIR KRFLCLGWGL PALVVAISVG FTKAKGYSTM 1080
NYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSK DGITDKKLKE RAGASLWSSC 1140
VVLPLLALTW MSAVLAVTDR RSALFQILFA VFDSLEGFVI VMVHCILRRE VQDAVKCRVV 1200
DRQEEGNGDS GGSFQNGHAQ LMTDFEKDVD LACRSVLNKD IAACRTATIT GTLKRPSLPE 1260
EEKLKLAHAK GPPTNFNSLP ANVSKLHLHG SPRYPGGPLP DFPNHSLTLK RDKAPKSSFV 1320
GDGDIFKKLD SELSRAQEKA LDTSYVILPT ATATLRPKPK EEPKYSIHID QMPQTRLIHL 1380
STAPEASLPA RSPPSRQPPS GGPPEAPPAQ PPPPPPPPPP PPQQPLPPPP NLEPAPPSLG 1440
DPGEPAAHPG PSTGPSTKNE NVATLSVSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN 1500
RKLQHAAEKD KEVLGPDSKP EKQQTPNKRP WESLRKAHGT PTWVKKELEP LQPSPLELRS 1560
VEWERSGATI PLVGQDIIDL QTEV 1585
Keyword

KW-0068--Autocatalytic cleavage
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR032471--GAIN_dom_N
IPR017981--GPCR_2-like
IPR008077--GPCR_2_brain_angio_inhib
IPR001879--GPCR_2_extracellular_dom
IPR000832--GPCR_2_secretin-like
IPR000203--GPS
IPR000884--TSP1_rpt
PROSITE

PS50227--G_PROTEIN_RECEP_F2_3
PS50261--G_PROTEIN_RECEP_F2_4
PS50221--GPS
PS50092--TSP1
Pfam

PF00002--7tm_2
PF16489--GAIN
PF01825--GPS
PF02793--HRM
PF00090--TSP_1
Gene Ontology

GO:0005911--C:cell-cell junction
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0004930--F:G-protein coupled receptor activity
GO:0007409--P:axonogenesis
GO:0007155--P:cell adhesion
GO:0007166--P:cell surface receptor signaling pathway
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0016525--P:negative regulation of angiogenesis
GO:0008285--P:negative regulation of cell proliferation
GO:0007422--P:peripheral nervous system development
GO:0051965--P:positive regulation of synapse assembly
GO:0007165--P:signal transduction