dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000663
Uniprot Accession O14511; NRG2_HUMAN;
Genbank Protein ID NP_001171864.1; NP_004874.1; NP_053584.1; NP_053585.1; NP_053586.1; XP_006714871.1; XP_006714873.1;
Genbank Nucleotide ID NM_001184935.1; NM_004883.2; NM_013981.3; NM_013982.2; NM_013983.2; XM_006714808.1; XM_006714810.2;
Protein Name Pro-neuregulin-2, membrane-bound isoform
Protein Synonyms/Alias
Gene Name NRG2
Gene Synonyms/Alias NTAK;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
21LEKGRCSSYSDSSSSPhosphoSitePlus22135298
23KGRCSSYSDSSSSSSPhosphoSitePlus22135298
27SSYSDSSSSSSERSSPhosphoSitePlus22135298
30SDSSSSSSERSSSSSPhosphoSitePlus22135298
34SSSSERSSSSSSSSSPhosphoSitePlus22135298
35SSSERSSSSSSSSSEPhosphoSitePlus22135298
36SSERSSSSSSSSSESPhosphoSitePlus22135298
37SERSSSSSSSSSESGPhosphoSitePlus22135298
38ERSSSSSSSSSESGSPhosphoSitePlus22135298
45SSSSESGSSSRSSSNPhosphoSitePlus22135298
47SSESGSSSRSSSNNSPhosphoSitePlus22135298
55RSSSNNSSISRPAAPcurated26074081
194PLERNQRYIFFLEPTPhosphoSitePlus22135298
579TAPPYHDSVDSLRDSPhosphoSitePlus22135298
582PYHDSVDSLRDSPHSPhosphoSitePlus22135298
767RDSLSLSSGSGGGSAPhosphoSitePlus22135298
820CPAADSRTYYSLDSHcurated25219547
821PAADSRTYYSLDSHScurated25219547
822AADSRTYYSLDSHSTcurated25219547
823ADSRTYYSLDSHSTRcurated25219547
Sequence
(Fasta)		MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 60
APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 120
QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 180
SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 240
KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 300
VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 360
YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQKAEE LYQKRVLTIT GICVALLVVG 420
IVCVVAYCKT KKQRKQMHNH LRQNMCPAHQ NRSLANGPSH PRLDPEEIQM ADYISKNVPA 480
TDHVIRRETE TTFSGSHSCS PSHHCSTATP TSSHRHESHT WSLERSESLT SDSQSGIMLS 540
SVGTSKCNSP ACVEARARRA AAYNLEERRR ATAPPYHDSV DSLRDSPHSE RYVSALTTPA 600
RLSPVDFHYS LATQVPTFEI TSPNSAHAVS LPPAAPISYR LAEQQPLLRH PAPPGPGPGP 660
GPGPGPGADM QRSYDSYYYP AAGPGPRRGT CALGGSLGSL PASPFRIPED DEYETTQECA 720
PPPPPRPRAR GASRRTSAGP RRWRRSRLNG LAAQRARAAR DSLSLSSGSG GGSASASDDD 780
ADDADGALAA ESTPFLGLRG AHDALRSDSP PLCPAADSRT YYSLDSHSTR ASSRHSRGPP 840
PRAKQDSAPL 851
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-1185--Reference proteome
KW-0964--Secreted
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003598--Ig_sub2
IPR002154--Neuregulin_C
PROSITE

PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS50835--IG_LIKE
Pfam

PF07679--I-set
PF02158--Neuregulin
Gene Ontology

GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0005102--F:receptor binding
GO:0000186--P:activation of MAPKK activity
GO:0007411--P:axon guidance
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0000165--P:MAPK cascade
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0048513--P:organ development
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0007265--P:Ras protein signal transduction
GO:0007165--P:signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway