| Tag |
Content |
| dbPAF ID |
dbPAF-0000662 |
| Uniprot Accession |
O14508; SOCS2_HUMAN; A8K3D1; O14542; O95102; Q9UKS5;
|
| Genbank Protein ID |
NP_001257396.1; NP_001257397.1; NP_001257398.1; NP_001257399.1; NP_001257400.1; NP_003868.1;
|
| Genbank Nucleotide ID |
NM_001270467.1; NM_001270468.1; NM_001270469.1; NM_001270470.1; NM_001270471.1; NM_003877.4;
|
| Protein Name |
Suppressor of cytokine signaling 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
SOCS2 |
| Gene Synonyms/Alias |
CIS2;SSI2;STATI2; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.Functional Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120
SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PSLQHLCRLT INKCTGAIWG 180
LPLPTRLKDY LEEYKFQV
199Fasta Sequence
>O14508|SOCS2|Homo sapiens(Human)
MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
|
| Interpro |
IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box
|
| PROSITE |
PS50001--SH2
PS50225--SOCS
|
| Pfam |
PF00017--SH2
PF07525--SOCS_box
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005131--F:growth hormone receptor binding
GO:0005159--F:insulin-like growth factor receptor binding
GO:0008269--F:JAK pathway signal transduction adaptor activity
GO:0004860--F:protein kinase inhibitor activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007568--P:aging
GO:0032870--P:cellular response to hormone stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0060397--P:JAK-STAT cascade involved in growth hormone signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:1904030--P:negative regulation of cyclin-dependent protein kinase activity
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0009967--P:positive regulation of signal transduction
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0009966--P:regulation of signal transduction
GO:0032355--P:response to estradiol
|
