Tag |
Content |
dbPAF ID |
dbPAF-0000661 |
Uniprot Accession |
O14503; BHE40_HUMAN; Q96TD3; |
Genbank Protein ID |
NP_003661.1; |
Genbank Nucleotide ID |
NM_003670.2; |
Protein Name |
Class E basic helix-loop-helix protein 40 |
Protein Synonyms/Alias |
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Gene Name |
BHLHE40 |
Gene Synonyms/Alias |
BHLHB2;DEC1;SHARP2;STRA13; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.Functional Description
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
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Phosphorylation Sites
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dbPAF PTMs: 10 |
Sequence (Fasta) | MERIPSAQPP PACLPKAPGL EHGDLPGMYP AHMYQVYKSR RGIKRSEDSK ETYKLPHRLI 60 EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT LKHVKALTNL IDQQQQKIIA 120 LQSGLQAGEL SGRNVETGQE MFCSGFQTCA REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS 180 ELLQGGTSRK PSDPAPKVMD FKEKPSSPAK GSEGPGKNCV PVIQRTFAHS SGEQSGSDTD 240 TDSGYGGESE KGDLRSEQPC FKSDHGRRFT MGERIGAIKQ ESEEPPTKKN RMQLSDDEGH 300 FTSSDLISSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPV LYPGLNASAA 360 ALSSFMNPDK ISAPLLMPQR LPSPLPAHPS VDSSVLLQAL KPIPPLNLET KD
413Fasta Sequence
>O14503|BHLHE40|Homo sapiens(Human) MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD
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Keyword |
KW-0090--Biological rhythms KW-0181--Complete proteome KW-0963--Cytoplasm KW-0238--DNA-binding KW-1017--Isopeptide bond KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation
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Interpro |
IPR011598--bHLH_dom IPR003650--Orange_dom
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PROSITE |
PS50888--BHLH PS51054--ORANGE
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Pfam |
PF07527--Hairy_orange PF00010--HLH
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Gene Ontology |
GO:0005794--C:Golgi apparatus GO:0005730--C:nucleolus GO:0005634--C:nucleus GO:0043425--F:bHLH transcription factor binding GO:0070888--F:E-box binding GO:0043426--F:MRF binding GO:0019904--F:protein domain specific binding GO:0046982--F:protein heterodimerization activity GO:0042803--F:protein homodimerization activity GO:0001102--F:RNA polymerase II activating transcription factor binding GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003714--F:transcription corepressor activity GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0032922--P:circadian regulation of gene expression GO:0007623--P:circadian rhythm GO:0043153--P:entrainment of circadian clock by photoperiod GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
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