dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000660
Uniprot Accession O14497; ARI1A_HUMAN; D3DPL1; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1;
Genbank Protein ID NP_006006.3; NP_624361.1;
Genbank Nucleotide ID NM_006015.4; NM_139135.2;
Protein Name AT-rich interactive domain-containing protein 1A
Protein Synonyms/Alias
Gene Name ARID1A
Gene Synonyms/Alias BAF250;BAF250A;C1orf4;OSA1;SMARCF1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 100 (View all)
PositionPeptidesSourceReferences ( PMIDs )
11QVAPAAASSLGNPPPPhosphoSitePlus22135298
58KAAAGQESEGPAVGPPhosphoSitePlus;curated22135298; 23186163
79ELQDGAESNGGGGGGdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 25627689; 22817900;
157FGQPYGRSPSAVAAAcurated26074081
229YPPPAPAYALSSPRGPhosphoSitePlus22135298
232PAPAYALSSPRGGTPPHOSIDA;SysPTM 2.0;curated21081558; 17081983; 19366988; 25003641
233APAYALSSPRGGTPGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated19690332; 16381945; 23193290; 18220336; 19276368; 19664995;
249GAAAAAGSKPPPSSSPhosphoPep 2.019060867
280AMGGGGPSAAGGGTPdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22199227; 22817900
286PSAAGGGTPQPTATPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 18988627; 22135298;
290GGGTPQPTATPTLNQcurated19690332
301TLNQLLTSPSSARGYdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 19664995; 19690332; 18988627;
316QGYPGGDYSGGPQDGPhosphoSitePlus22135298
350AAAAAAASGGAQQRScurated26074081
357SGGAQQRSHHAPMSPcurated22199227; 23186163; 24667141
363RSHHAPMSPGSSGGGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 19413330; 19690332; 16381945; 23193290; 18847512;
366HAPMSPGSSGGGGQPPhosphoSitePlus;curated22135298; 22817900; 23836654; 24961811
367APMSPGSSGGGGQPLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
377GGQPLARTPQPSSPMPhosphoSitePlus;curated22135298; 25627689; 23898821
381LARTPQPSSPMDQMGPhosphoSitePlus;curated22135298; 22199227; 26074081
Sequence
(Fasta)		MAAQVAPAAA SSLGNPPPPP PSELKKAEQQ QREEAGGEAA AAAAAERGEM KAAAGQESEG 60
PAVGPPQPLG KELQDGAESN GGGGGGGAGS GGGPGAEPDL KNSNGNAGPR PALNNNLTEP 120
PGGGGGGSSD GVGAPPHSAA AALPPPAYGF GQPYGRSPSA VAAAAAAVFH QQHGGQQSPG 180
LAALQSGGGG GLEPYAGPQQ NSHDHGFPNH QYNSYYPNRS AYPPPAPAYA LSSPRGGTPG 240
SGAAAAAGSK PPPSSSASAS SSSSSFAQQR FGAMGGGGPS AAGGGTPQPT ATPTLNQLLT 300
SPSSARGYQG YPGGDYSGGP QDGGAGKGPA DMASQCWGAA AAAAAAAAAS GGAQQRSHHA 360
PMSPGSSGGG GQPLARTPQP SSPMDQMGKM RPQPYGGTNP YSQQQGPPSG PQQGHGYPGQ 420
PYGSQTPQRY PMTMQGRAQS AMGGLSYTQQ IPPYGQQGPS GYGQQGQTPY YNQQSPHPQQ 480
QQPPYSQQPP SQTPHAQPSY QQQPQSQPPQ LQSSQPPYSQ QPSQPPHQQS PAPYPSQQST 540
TQQHPQSQPP YSQPQAQSPY QQQQPQQPAP STLSQQAAYP QPQSQQSQQT AYSQQRFPPP 600
QELSQDSFGS QASSAPSMTS SKGGQEDMNL SLQSRPSSLP DLSGSIDDLP MGTEGALSPG 660
VSTSGISSSQ GEQSNPAQSP FSPHTSPHLP GIRGPSPSPV GSPASVAQSR SGPLSPAAVP 720
GNQMPPRPPS GQSDSIMHPS MNQSSIAQDR GYMQRNPQMP QYSSPQPGSA LSPRQPSGGQ 780
IHTGMGSYQQ NSMGSYGPQG GQYGPQGGYP RQPNYNALPN ANYPSAGMAG GINPMGAGGQ 840
MHGQPGIPPY GTLPPGRMSH ASMGNRPYGP NMANMPPQVG SGMCPPPGGM NRKTQETAVA 900
MHVAANSIQN RPPGYPNMNQ GGMMGTGPPY GQGINSMAGM INPQGPPYSM GGTMANNSAG 960
MAASPEMMGL GDVKLTPATK MNNKADGTPK TESKSKKSSS STTTNEKITK LYELGGEPER 1020
KMWVDRYLAF TEEKAMGMTN LPAVGRKPLD LYRLYVSVKE IGGLTQVNKN KKWRELATNL 1080
NVGTSSSAAS SLKKQYIQCL YAFECKIERG EDPPPDIFAA ADSKKSQPKI QPPSPAGSGS 1140
MQGPQTPQST SSSMAEGGDL KPPTPASTPH SQIPPLPGMS RSNSVGIQDA FNDGSDSTFQ 1200
KRNSMTPNPG YQPSMNTSDM MGRMSYEPNK DPYGSMRKAP GSDPFMSSGQ GPNGGMGDPY 1260
SRAAGPGLGN VAMGPRQHYP YGGPYDRVRT EPGIGPEGNM STGAPQPNLM PSNPDSGMYS 1320
PSRYPPQQQQ QQQQRHDSYG NQFSTQGTPS GSPFPSQQTT MYQQQQQNYK RPMDGTYGPP 1380
AKRHEGEMYS VPYSTGQGQP QQQQLPPAQP QPASQQQAAQ PSPQQDVYNQ YGNAYPATAT 1440
AATERRPAGG PQNQFPFQFG RDRVSAPPGT NAQQNMPPQM MGGPIQASAE VAQQGTMWQG 1500
RNDMTYNYAN RQSTGSAPQG PAYHGVNRTD EMLHTDQRAN HEGSWPSHGT RQPPYGPSAP 1560
VPPMTRPPPS NYQPPPSMQN HIPQVSSPAP LPRPMENRTS PSKSPFLHSG MKMQKAGPPV 1620
PASHIAPAPV QPPMIRRDIT FPPGSVEATQ PVLKQRRRLT MKDIGTPEAW RVMMSLKSGL 1680
LAESTWALDT INILLYDDNS IMTFNLSQLP GLLELLVEYF RRCLIEIFGI LKEYEVGDPG 1740
QRTLLDPGRF SKVSSPAPME GGEEEEELLG PKLEEEEEEE VVENDEEIAF SGKDKPASEN 1800
SEEKLISKFD KLPVKIVQKN DPFVVDCSDK LGRVQEFDSG LLHWRIGGGD TTEHIQTHFE 1860
SKTELLPSRP HAPCPPAPRK HVTTAEGTPG TTDQEGPPPD GPPEKRITAT MDDMLSTRSS 1920
TLTEDGAKSS EAIKESSKFP FGISPAQSHR NIKILEDEPH SKDETPLCTL LDWQDSLAKR 1980
CVCVSNTIRS LSFVPGNDFE MSKHPGLLLI LGKLILLHHK HPERKQAPLT YEKEEEQDQG 2040
VSCNKVEWWW DCLEMLRENT LVTLANISGQ LDLSPYPESI CLPVLDGLLH WAVCPSAEAQ 2100
DPFSTLGPNA VLSPQRLVLE TLSKLSIQDN NVDLILATPP FSRLEKLYST MVRFLSDRKN 2160
PVCREMAVVL LANLAQGDSL AARAIAVQKG SIGNLLGFLE DSLAATQFQQ SQASLLHMQN 2220
PPFEPTSVDM MRRAARALLA LAKVDENHSE FTLYESRLLD ISVSPLMNSL VSQVICDVLF 2280
LIGQS 2286
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0991--Mental retardation
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR001606--ARID_dom
IPR016024--ARM-type_fold
IPR021906--BAF250/Osa
IPR030094--BAF250a
PROSITE

PS51011--ARID
Pfam

PF01388--ARID
PF12031--DUF3518
Gene Ontology

GO:0071565--C:nBAF complex
GO:0071564--C:npBAF complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016514--C:SWI/SNF complex
GO:0003677--F:DNA binding
GO:0016922--F:ligand-dependent nuclear receptor binding
GO:0003713--F:transcription coactivator activity
GO:0030521--P:androgen receptor signaling pathway
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0003205--P:cardiac chamber development
GO:0055007--P:cardiac muscle cell differentiation
GO:0006338--P:chromatin remodeling
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0030900--P:forebrain development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0006344--P:maintenance of chromatin silencing
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0006337--P:nucleosome disassembly
GO:0042766--P:nucleosome mobilization
GO:0003408--P:optic cup formation involved in camera-type eye development
GO:0060674--P:placenta blood vessel development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:1901998--P:toxin transport
GO:0006351--P:transcription, DNA-templated