| Tag |
Content |
| dbPAF ID |
dbPAF-0000659 |
| Uniprot Accession |
O14495; LPP3_HUMAN; B2R651; D3DQ52; Q5U0F7; Q96GW0; Q99782;
|
| Genbank Protein ID |
NP_003704.3;
|
| Genbank Nucleotide ID |
NM_003713.4;
|
| Protein Name |
Lipid phosphate phosphohydrolase 3 |
| Protein Synonyms/Alias |
PAP2-beta;Phosphatidate phosphohydrolase type 2b;Phosphatidic acid phosphatase 2b;PAP-2b;PAP2b;Vascular endothelial growth factor and type I collagen-inducible protein;VCIP; |
| Gene Name |
PPAP2B |
| Gene Synonyms/Alias |
LPP3; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.Functional Description
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK 60
PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN 120
PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR 180
CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY 240
TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD 300
IIDRNNHHNM M
312Fasta Sequence
>O14495|PPAP2B|Homo sapiens(Human)
MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVDIIDRNNHHNMM
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR028675--LPP3
IPR000326--P_Acid_Pase_2/haloperoxidase
|
| PROSITE |
|
| Pfam |
PF01569--PAP2
|
| Gene Ontology |
GO:0005912--C:adherens junction
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0042577--F:lipid phosphatase activity
GO:0008195--F:phosphatidate phosphatase activity
GO:0004721--F:phosphoprotein phosphatase activity
GO:0042392--F:sphingosine-1-phosphate phosphatase activity
GO:0060020--P:Bergmann glial cell differentiation
GO:0001568--P:blood vessel development
GO:0044329--P:canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion
GO:0044328--P:canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration
GO:0044330--P:canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0001702--P:gastrulation with mouth forming second
GO:0008354--P:germ cell migration
GO:0034109--P:homotypic cell-cell adhesion
GO:0006629--P:lipid metabolic process
GO:0001933--P:negative regulation of protein phosphorylation
GO:0046839--P:phospholipid dephosphorylation
GO:0006644--P:phospholipid metabolic process
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0006470--P:protein dephosphorylation
GO:0050821--P:protein stabilization
GO:1902068--P:regulation of sphingolipid mediated signaling pathway
GO:0030111--P:regulation of Wnt signaling pathway
GO:0044281--P:small molecule metabolic process
GO:0030148--P:sphingolipid biosynthetic process
GO:0006665--P:sphingolipid metabolic process
|
