dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000658
Uniprot Accession O14494; LPP1_HUMAN; B7ZKN8; G3XA95; O60457; O60463; Q17RZ4;
Genbank Protein ID NP_003702.2; NP_795714.1;
Genbank Nucleotide ID NM_003711.3; NM_176895.2;
Protein Name Lipid phosphate phosphohydrolase 1
Protein Synonyms/Alias PAP2-alpha;Phosphatidate phosphohydrolase type 2a;Phosphatidic acid phosphatase 2a;PAP-2a;PAP2a;
Gene Name PPAP2A
Gene Synonyms/Alias LPP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
185CMLFVALYLQARMKGPhosphoSitePlus22135298
201WARLLRPTLQFGLVAPhosphoSitePlus22135298
254SDFFKERTSFKERKEPhosphoSitePlus22135298
255DFFKERTSFKERKEEPhosphoSitePlus22135298
264KERKEEDSHTTLHETPhosphoSitePlus;curated22135298; 25627689
266RKEEDSHTTLHETPTPhosphoSitePlus;curated22135298; 25627689
267KEEDSHTTLHETPTTPhosphoSitePlus;curated22135298; 25627689
271SHTTLHETPTTGNHYPhosphoSitePlus;curated22135298; 25627689
273TTLHETPTTGNHYPSPhosphoSitePlus22135298
278TPTTGNHYPSNHQP-curated25627689
Sequence
(Fasta)		MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG 60
GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK 120
YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML 180
FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI 240
LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP 285
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR028670--LPP1
IPR000326--P_Acid_Pase_2/haloperoxidase
PROSITE
Pfam

PF01569--PAP2
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0042577--F:lipid phosphatase activity
GO:0008195--F:phosphatidate phosphatase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0008354--P:germ cell migration
GO:0030518--P:intracellular steroid hormone receptor signaling pathway
GO:0006629--P:lipid metabolic process
GO:0008285--P:negative regulation of cell proliferation
GO:0046839--P:phospholipid dephosphorylation
GO:0006644--P:phospholipid metabolic process
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0019216--P:regulation of lipid metabolic process
GO:0044281--P:small molecule metabolic process
GO:0030148--P:sphingolipid biosynthetic process
GO:0006665--P:sphingolipid metabolic process