dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000657
Uniprot Accession O14493; CLD4_HUMAN;
Genbank Protein ID NP_001296.1;
Genbank Nucleotide ID NM_001305.4;
Protein Name Claudin-4
Protein Synonyms/Alias Clostridium perfringens enterotoxin receptor;CPE-R;CPE-receptor;Williams-Beuren syndrome chromosomal region 8 protein;
Gene Name CLDN4
Gene Synonyms/Alias CPER;CPETR1;WBSCR8;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a major role in tight junction-specific obliteration of the intercellular space.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
193PPRTDKPYSAKYSAAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
194PRTDKPYSAKYSAARdbPTM 3.0;PhosphoSitePlus;curated18786529; 16381945; 23193290; 22135298; 22817900; 25849741
197DKPYSAKYSAARSAAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900; 24260401
198KPYSAKYSAARSAAAPhosphoSitePlus;curated22135298; 23898821; 23090842; 25849741
202AKYSAARSAAASNYVPhosphoSitePlus;curated22135298; 23911959; 25849741
206AARSAAASNYV----PhosphoSitePlus;curated22135298; 23911959
208RSAAASNYV------dbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;curated16236711; 16381945; 23193290; 18083107; 22322096; 19060867;
Sequence
(Fasta)		MASMGLQVMG IALAVLGWLA VMLCCALPMW RVTAFIGSNI VTSQTIWEGL WMNCVVQSTG 60
QMQCKVYDSL LALPQDLQAA RALVIISIIV AALGVLLSVV GGKCTNCLED ESAKAKTMIV 120
AGVVFLLAGL MVIVPVSWTA HNIIQDFYNP LVASGQKREM GASLYVGWAA SGLLLLGGGL 180
LCCNCPPRTD KPYSAKYSAA RSAAASNYV
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0856--Williams-Beuren syndrome
Interpro

IPR006187--Claudin
IPR003550--Claudin4
IPR017974--Claudin_CS
IPR004031--PMP22/EMP/MP20/Claudin
PROSITE

PS01346--CLAUDIN
Pfam

PF00822--PMP22_Claudin
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016327--C:apicolateral plasma membrane
GO:0009925--C:basal plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005887--C:integral component of plasma membrane
GO:0016328--C:lateral plasma membrane
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0005198--F:structural molecule activity
GO:0004888--F:transmembrane signaling receptor activity
GO:0016338--P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0007623--P:circadian rhythm
GO:0061436--P:establishment of skin barrier
GO:0007565--P:female pregnancy
GO:0032570--P:response to progesterone
GO:0007165--P:signal transduction