| Tag |
Content |
| dbPAF ID |
dbPAF-0000656 |
| Uniprot Accession |
O14492; SH2B2_HUMAN; A6ND74;
|
| Genbank Protein ID |
NP_066189.3; XP_005277034.1; XP_005277036.1; XP_011514043.1;
|
| Genbank Nucleotide ID |
NM_020979.4; XM_005276977.3; XM_005276979.2; XM_011515741.1;
|
| Protein Name |
SH2B adapter protein 2 |
| Protein Synonyms/Alias |
Adapter protein with pleckstrin homology and Src homology 2 domains;SH2 and PH domain-containing adapter protein APS; |
| Gene Name |
SH2B2 |
| Gene Synonyms/Alias |
APS; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.Functional Description
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MNGAGPGPAA AAPVPVPVPV PDWRQFCELH AQAAAVDFAH KFCRFLRDNP AYDTPDAGAS 60
FSRHFAANFL DVFGEEVRRV LVAGPTTRGA AVSAEAMEPE LADTSALKAA PYGHSRSSED 120
VSTHAATKAR VRKGFSLRNM SLCVVDGVRD MWHRRASPEP DAAAAPRTAE PRDKWTRRLR 180
LSRTLAAKVE LVDIQREGAL RFMVADDAAA GSGGSAQWQK CRLLLRRAVA EERFRLEFFV 240
PPKASRPKVS IPLSAIIEVR TTMPLEMPEK DNTFVLKVEN GAEYILETID SLQKHSWVAD 300
IQGCVDPGDS EEDTELSCTR GGCLASRVAS CSCELLTDAV DLPRPPETTA VGAVVTAPHS 360
RGRDAVRESL IHVPLETFLQ TLESPGGSGS DSNNTGEQGA ETDPEAEPEL ELSDYPWFHG 420
TLSRVKAAQL VLAGGPRNHG LFVIRQSETR PGEYVLTFNF QGKAKHLRLS LNGHGQCHVQ 480
HLWFQSVLDM LRHFHTHPIP LESGGSADIT LRSYVRAQDP PPEPGPTPPA APASPACWSD 540
SPGQHYFSSL AAAACPPASP SDAAGASSSS ASSSSAASGP APPRPVEGQL SARSRSNSAE 600
RLLEAVAATA AEEPPEAAPG RARAVENQYS FY
633Fasta Sequence
>O14492|SH2B2|Homo sapiens(Human)
MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARAVENQYSFY
|
| Keyword |
KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
|
| Interpro |
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR015012--Phe_ZIP
IPR000980--SH2
IPR030523--SH2B
IPR030520--SH2B2
|
| PROSITE |
PS50003--PH_DOMAIN
PS50001--SH2
|
| Pfam |
PF00169--PH
PF08916--Phe_ZIP
PF00017--SH2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0008269--F:JAK pathway signal transduction adaptor activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0004871--F:signal transducer activity
GO:0007596--P:blood coagulation
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0009967--P:positive regulation of signal transduction
GO:0046425--P:regulation of JAK-STAT cascade
GO:0007165--P:signal transduction
|
