dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000654
Uniprot Accession O14470; SSR2_SCHPO; P78877;
Genbank Protein ID NP_593800.1;
Genbank Nucleotide ID NM_001019229.2;
Protein Name SWI/SNF and RSC complexes subunit ssr2
Protein Synonyms/Alias
Gene Name ssr2
Gene Synonyms/Alias SPAC23H3.10;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
175LNAMEQTSPKEEDEKdbPTM 3.0;UniProt18257517; 16381945; 23193290
306QKLQGDFSPFKKGFLdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MTLDQVRIPF LVEQTYPIIV PSYAGWFDMS KIHDIERRSN PEFFNGKSPL KTPSIYKDYR 60
DFMINSYRLE PNEYLTVTAC RRNLVGDVCA IIRVHAFLEQ WGLINYQIDP ETRPAFRLPP 120
ISGHVQAISN TPIVTQEMLA QHPPPSTVGG SSSQEFVKLE EKHYSPSLNA MEQTSPKEED 180
EKSDKVPRVD KVCFTCGVNC SQTWYHNLKN KKYDICPNCY KQGRFSSSFN SSDFLCMDAI 240
DFNHDEEKPW SNQETLLLLE AIETYGDDWN QIALHVGSRT KEQCLIHFLQ IPIEDPYRQK 300
LQGDFSPFKK GFLPFDENEN PVLSTLTYLA SIVQQGMKER KQNESVKQGE TSFGNSEFKN 360
PLERVAYYAL KSAAQKAKLI AAFENRQLRR LVFSLIQAQL EKLQLKMKVL EQLEKMCSLE 420
LSELDLRGKN LLLSRLSTKK MLLAFNKKLE EAVNLGGEDG LKIIDDLMST EHAEALLTFE 480
MPTATTVSPL SKQYPDKFRT IAL 504
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR009057--Homeodomain-like
IPR001005--SANT/Myb
IPR017884--SANT_dom
IPR032451--SMARCC_C
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom
IPR000433--Znf_ZZ
PROSITE

PS51293--SANT
PS50934--SWIRM
Pfam

PF00249--Myb_DNA-binding
PF04433--SWIRM
PF16495--SWIRM-assoc_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0016586--C:RSC complex
GO:0016514--C:SWI/SNF complex
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated