dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000651
Uniprot Accession O14460; EF2_SCHPO; P78802; Q9USG7; Q9USZ9; Q9UT64;
Genbank Protein ID NP_587863.1; XP_001713073.1;
Genbank Nucleotide ID NM_001022856.2; XM_001713021.2;
Protein Name Elongation factor 2
Protein Synonyms/Alias
Gene Name eft202
Gene Synonyms/Alias eft2;eft2-1;SPAC513.01c;SPAPYUK71.04c;SPCP31B10.07;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
34HVDHGKSTLTDSLVQcurated22817900
38GKSTLTDSLVQKAGIdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
568VSYRESVSEPSSMTAdbPTM 3.0;UniProt18257517; 16381945; 23193290
574VSEPSSMTALSKSPNdbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)		MVAFTPEEVR NLMGKPSNVR NMSVIAHVDH GKSTLTDSLV QKAGIISAAK AGDARFMDTR 60
ADEQERGVTI KSTAISLFAE MTDDDMKDMK EPADGTDFLV NLIDSPGHVD FSSEVTAALR 120
VTDGALVVVD TIEGVCVQTE TVLRQALGER IRPVVVVNKV DRALLELQIS QEELYQNFAR 180
VVESVNVVIS TYYDKVLGDC QVFPDKGTVA FASGLHGWAF TVRQFANRYA KKFGIDRNKM 240
MQRLWGENYF NPKTKKWSKS ATDANGNSNQ RAFNMFILDP IYRIFDAVMN SRKDEVFTLL 300
SKLEVTIKPD EKELEGKALL KVVMRKFLPA ADALMEMIVL HLPSPKTAQQ YRAETLYEGP 360
MDDECAVGIR NCDANAPLMI YVSKMVPTSD RGRFYAFGRV FSGTVRSGLK VRIQGPNYVP 420
GKKDDLFIKA IQRTVLMMGS RIEPIEDCPA GNIIGLVGVD QFLVKSGTLT TSEVAHNMKV 480
MKFSVSPVVQ VAVEVKNGND LPKLVEGLKR LSKSDPCVLC TTSESGEHIV AGAGELHLEI 540
CLKDLQEDHA GIPLKISPPV VSYRESVSEP SSMTALSKSP NKHNRIFMTA EPMSEELSVA 600
IETGHVNPRD DFKVRARIMA DEFGWDVTDA RKIWCFGPDT TGANVVVDQT KAVAYLNEIK 660
DSVVAAFAWA SKEGPMFEEN LRSCRFNILD VVLHADAIHR GGGQIIPTAR RVVYASTLLA 720
SPIIQEPVFL VEIQVSENAM GGIYSVLNKK RGHVFSEEQR VGTPLYNIKA YLPVNESFGF 780
TGELRQATAG QAFPQLVFDH WSPMSGDPLD PTSKPGQIVC EARKRKGLKE NVPDYTEYYD 840
RL 843
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0251--Elongation factor
KW-0342--GTP-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
Interpro

IPR009022--EFG_III-V
IPR000640--EFG_V
IPR031157--G_TR_CS
IPR027417--P-loop_NTPase
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr
IPR005225--Small_GTP-bd_dom
IPR000795--TF_GTP-bd_dom
IPR009000--Transl_B-barrel
IPR005517--Transl_elong_EFG/EF2_IV
IPR004161--Transl_elong_EFTu/EF1A_2
PROSITE

PS00301--G_TR_1
PS51722--G_TR_2
Pfam

PF00679--EFG_C
PF14492--EFG_II
PF03764--EFG_IV
PF03144--GTP_EFTU_D2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0003746--F:translation elongation factor activity
GO:0002182--P:cytoplasmic translational elongation