dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000644
Uniprot Accession O14360; NAF1_SCHPO;
Genbank Protein ID NP_596270.1;
Genbank Nucleotide ID NM_001022191.2;
Protein Name H/ACA ribonucleoprotein complex non-core subunit NAF1
Protein Synonyms/Alias Nuclear assembly factor 1;
Gene Name naf1
Gene Synonyms/Alias SPBC30D10.15;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex (By similarity).
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
224AESMAPSTPPKTVNEcurated22817900
361YDEEINPSEQEFSDDdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
366NPSEQEFSDDEAEVAdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)
MYPHLPCKIP GLSLIYDDES KVEKSKQLST NASSSNFVKE DQIPSNLSID NINTPQGDPI 60
DKNNLNTNTE NNLPNIVNFQ NISSANSGEI KQKDNEILFS STEDINQHKE NYQDENKIDL 120
LDVALANPKD CVVPSSGLLM PKEEFISNEE VGIPATNSSE KSNVKIADEI AEVTHSNSSI 180
GKSSADLSSD SSSDSESNTS FSETDVEEEK AEEKSDAESM APSTPPKTVN ELPEQIYEKP 240
EIVLQPNSLI EPLGKIIQVL KREVVVKSDI DDEKIVFDEK TVLCFEDRSI IGYIHETFGP 300
VSSPYYIVRF STEEECSAIN ACMGRPVFYV PTMANKIDPE PLKYIKGSDA SNVYDEEINP 360
SEQEFSDDEA EVAAKQLKKK RKRKAKSMVS GNQALPGEAN FQSLNQNNVR NYPFYQTNQG 420
SNPPAKRFTQ EPPSSSLYSL SESSINYSTQ SPMYYNYNYP QPSFPPFHPI YNDSIGYYSQ 480
ANPQMYYANQ VSAPPPQGSF DPNSKFYRNS SDSYRK 517
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0690--Ribosome biogenesis
KW-0694--RNA-binding
KW-0698--rRNA processing

Interpro

IPR007504--H/ACA_rnp_Gar1/Naf1
IPR009000--Transl_B-barrel

PROSITE
Pfam

PF04410--Gar1

Gene Ontology

GO:0005635--C:nuclear envelope
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030529--C:ribonucleoprotein complex
GO:0030515--F:snoRNA binding
GO:0000493--P:box H/ACA snoRNP assembly
GO:0001522--P:pseudouridine synthesis
GO:0006364--P:rRNA processing