dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000643
Uniprot Accession O14356; TOR1_SCHPO;
Genbank Protein ID NP_596275.1;
Genbank Nucleotide ID NM_001022196.2;
Protein Name Phosphatidylinositol 3-kinase tor1
Protein Synonyms/Alias
Gene Name tor1
Gene Synonyms/Alias SPBC30D10.10c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Phosphatidylinositol 3-kinase homolog required for G1 progression and entry into stationary phase. Also required for the onset of meiosis and sporulation under nitrogen and carbon starvation conditions.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
2234NWRLMTKSSFGASTTcurated22817900
Sequence
(Fasta)
MEYFSDLKNK NESIQLAAAD QLKEFVHSST KELSGESLAR FNNDINRRIF ELIHSHDSHE 60
RFGGILAIGK LIEFESEGDV TNLSRYANYL RMTLPSTDWH SMELSAKVLG HLAASGGTLA 120
AEFVEFEVQR AFEWLQGDRQ EQKRMAAILI IKALAQNSPT LVYLYISEIF QNLWTGLRDP 180
KPLIRETAAD ALGASLDVVC QREAKVQLQC FNEVLLQAEH GLRQSSVEYL HGSLLAYKEL 240
FEKSGSFIRE HYTEFCDLAL RLREHRDNSI RRCIVFLLPT LSEYNPKKFQ QRYLDSFMVY 300
LLSHIRKDKE KSLAFEAIGR IAMAVNEAMI PYLQNILKVI RDTLTAKVRE KTQYEKPVFE 360
CIGMLAAAVK LELLEDSRSL LGLIFSCELS VHLRQALVKM AENIPPLLAP IQERLLNMVS 420
QILTGKNFEI RTNDTYTPSF TNIYSAREPD QRSKSTESII LALETLGTFN FTGYSLISFI 480
QESVLSYLEN DNSEIRIAAA RTCCQVFARD PICRKTNPLA VESVAEVLEK LLTLGIADSD 540
PKIRETVLSL LDERFDRHLA HPDNIRCLFI ALNDEVFSIR EIAIIIIGRL ALYNPAHVMP 600
SLRKTIIQLL SDMEYSGNSR QKEESAQLLK LLVSKARTLI KPYIQSIIHV ILPKAADTSP 660
GVSSAIISAL GELASVEGED MPVDVRGSFM KLILVNLQDQ SSTLKRLASL KCLRKLCGRS 720
GYVIQPYLDY PPLLGALIGI LQSEQPTPIR REVLRTLGVL GALDPYTYLT TEEVSDDLQS 780
SHNNAHGVPQ ISAAQYPSLE NYAMVAVVTL IGILKDSSLS MHHSSVVQAV MHICSQMGSK 840
STVFLPQVVP TFLQVMQSLS ASSAEFYFQQ LTTLTSIIGP NIRDYVSDIF NLSKVFWEST 900
TSLLLVILEL IDAIAIALQD EFKFYLPQIL SCMLKAFSLD NTSSRSVSYK VLQSFVIFGS 960
NIEEYMHLVL PVIIRSFERD TIPLGFRKSA LKCIAQLFQS VNFSDHASRI IHPLVRMLGK 1020
SNGDLRAVIM DTLCAIVSQL GYDYSIFIPM VNKVLVSHKI SHPAYELLVS RLLKGEPLPK 1080
DVVVKEFKPR PSTKPFSTQD EVLTKLPVDQ ASLKAAWESS QKLTRDDWQD WIRRISIELL 1140
KESPSSALRS CSTLAGIYHP LARDLFNVSF LSCWDELTES NKKNLVKSIE LAMNAPNISV 1200
EILQTLLNLA EYMEREDHTL PIPIKVISAH ASKCNVYAKA LHYTELQFVQ ETKEEVSIST 1260
IESLITINNH LQQSDAAVGM LQYTKEHKQF SLKETWYEKL HRWDDALAAY EHREREGDSS 1320
FEINIGKLRC YYALGDWDHL SELAQKAWVT SEQEHREAIA PLAAAAAWGL GQWNLISEYV 1380
SAMDRDPQDK EFFSAISAVH LGQYNKAYGH IERHRDILVN DLSSIIGESY NRAYGIMVKS 1440
QMLSELEEII DYKKNMQYEN NLDSLKKTWR KRLEGCQKNV DVWHNTLRFR ALVLSPQDSP 1500
EMWIKLADLC RRSDRLKLSN QCLTYLMGRD PSNAYPLDSL KLLNPHVVYT YLKYLWATDQ 1560
KNIAVSELEE FTSYLSSKHG YKMGDSSKLV DILASSSVSS EERSFLARCF HKLGKWKKSL 1620
QDSVNQESVR DILNCYFYAT LFDKSWYKAW HSWALANFEV VGYYEQTEHG VTQDMYEQYI 1680
VPAIKGFFHS SVLNQKNSLQ DILRLLNLWF KFGEHSDVAA AIVEGFSNVP MDTWLEVIPQ 1740
LIARIHTSSS SVRASVHQLL SDIGRVHPQA LVYSLTVSSK STNPQQKHSA KSIMDSMLSH 1800
SDTLVRQALL VSQELIRVAI LWHELWYEGL EEASQAYFSD HDISLMIDIV KPLHETLEKG 1860
PSTLSEISFA QTFGYDLRKA RSYWQKFLQD GDPTELNQSW DLYYQVFRRI QKQLPRIKHL 1920
ELQYVSPKLL DACDLELAVP GTYGHNKPVI RISHFHHTFE VISSKQRPRR LTIHGSDGKD 1980
YQYVLKGHED LRQDERVMQL FGLCNTLLTT DSETFKRRLN IERYTVIPLS PNSGLLGWVP 2040
HSDTLHFLIK EFRSKRNILL NLEHRMMLQM APDCDSLTLL QKLEVFEYVM ANTDGYDLYH 2100
VLWLKSRSSE AWLDRRTSYT QSLAVMSMVG YILGLGDRHP SNLMMDRYSG KIIHIDFGDC 2160
FEVAMHREKF PEKIPFRLTR MLINAMEVSG IQGTYKITCE LVMRVLRSNT ESLMAVLEAF 2220
VYDPLINWRL MTKSSFGAST TLRPTSSSVE EKGRSYTHRA RHADYAALSE TNGVNAEGLN 2280
ERSIQVLKRV SNKLTGKDFD LKEQLPVKAQ VEKLIQQATA PENLCRCYVG WCSFW 2336
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR024585--DUF3385_TOR
IPR003152--FATC_dom
IPR011009--Kinase-like_dom
IPR000403--PI3/4_kinase_cat_dom
IPR018936--PI3/4_kinase_CS
IPR003151--PIK-rel_kinase_FAT
IPR014009--PIK_FAT
IPR009076--Rapamycin-bd_dom
IPR026683--TOR

PROSITE

PS51189--FAT
PS51190--FATC
PS00915--PI3_4_KINASE_1
PS00916--PI3_4_KINASE_2
PS50290--PI3_4_KINASE_3

Pfam

PF11865--DUF3385
PF02259--FAT
PF02260--FATC
PF00454--PI3_PI4_kinase
PF08771--Rapamycin_bind

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031932--C:TORC2 complex
GO:0016303--F:1-phosphatidylinositol-3-kinase activity
GO:0005524--F:ATP binding
GO:0008144--F:drug binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007569--P:cell aging
GO:0007049--P:cell cycle
GO:0006995--P:cellular response to nitrogen starvation
GO:0071470--P:cellular response to osmotic stress
GO:0000724--P:double-strand break repair via homologous recombination
GO:0018105--P:peptidyl-serine phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0031139--P:positive regulation of conjugation with cellular fusion
GO:0031929--P:TOR signaling