Tag |
Content |
dbPAF ID |
dbPAF-0000643 |
Uniprot Accession |
O14356; TOR1_SCHPO; |
Genbank Protein ID |
NP_596275.1; |
Genbank Nucleotide ID |
NM_001022196.2; |
Protein Name |
Phosphatidylinositol 3-kinase tor1 |
Protein Synonyms/Alias |
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Gene Name |
tor1 |
Gene Synonyms/Alias |
SPBC30D10.10c; |
Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
NCBI Taxa ID |
284812 |
Functional Description (View all) |
Phosphatidylinositol 3-kinase homolog required for G1 progression and entry into stationary phase. Also required for the onset of meiosis and sporulation under nitrogen and carbon starvation conditions.Functional Description
Phosphatidylinositol 3-kinase homolog required for G1 progression and entry into stationary phase. Also required for the onset of meiosis and sporulation under nitrogen and carbon starvation conditions.
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
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2234 | NWRLMTKSSFGASTT | curated | 22817900 |
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Sequence (Fasta) | MEYFSDLKNK NESIQLAAAD QLKEFVHSST KELSGESLAR FNNDINRRIF ELIHSHDSHE 60 RFGGILAIGK LIEFESEGDV TNLSRYANYL RMTLPSTDWH SMELSAKVLG HLAASGGTLA 120 AEFVEFEVQR AFEWLQGDRQ EQKRMAAILI IKALAQNSPT LVYLYISEIF QNLWTGLRDP 180 KPLIRETAAD ALGASLDVVC QREAKVQLQC FNEVLLQAEH GLRQSSVEYL HGSLLAYKEL 240 FEKSGSFIRE HYTEFCDLAL RLREHRDNSI RRCIVFLLPT LSEYNPKKFQ QRYLDSFMVY 300 LLSHIRKDKE KSLAFEAIGR IAMAVNEAMI PYLQNILKVI RDTLTAKVRE KTQYEKPVFE 360 CIGMLAAAVK LELLEDSRSL LGLIFSCELS VHLRQALVKM AENIPPLLAP IQERLLNMVS 420 QILTGKNFEI RTNDTYTPSF TNIYSAREPD QRSKSTESII LALETLGTFN FTGYSLISFI 480 QESVLSYLEN DNSEIRIAAA RTCCQVFARD PICRKTNPLA VESVAEVLEK LLTLGIADSD 540 PKIRETVLSL LDERFDRHLA HPDNIRCLFI ALNDEVFSIR EIAIIIIGRL ALYNPAHVMP 600 SLRKTIIQLL SDMEYSGNSR QKEESAQLLK LLVSKARTLI KPYIQSIIHV ILPKAADTSP 660 GVSSAIISAL GELASVEGED MPVDVRGSFM KLILVNLQDQ SSTLKRLASL KCLRKLCGRS 720 GYVIQPYLDY PPLLGALIGI LQSEQPTPIR REVLRTLGVL GALDPYTYLT TEEVSDDLQS 780 SHNNAHGVPQ ISAAQYPSLE NYAMVAVVTL IGILKDSSLS MHHSSVVQAV MHICSQMGSK 840 STVFLPQVVP TFLQVMQSLS ASSAEFYFQQ LTTLTSIIGP NIRDYVSDIF NLSKVFWEST 900 TSLLLVILEL IDAIAIALQD EFKFYLPQIL SCMLKAFSLD NTSSRSVSYK VLQSFVIFGS 960 NIEEYMHLVL PVIIRSFERD TIPLGFRKSA LKCIAQLFQS VNFSDHASRI IHPLVRMLGK 1020 SNGDLRAVIM DTLCAIVSQL GYDYSIFIPM VNKVLVSHKI SHPAYELLVS RLLKGEPLPK 1080 DVVVKEFKPR PSTKPFSTQD EVLTKLPVDQ ASLKAAWESS QKLTRDDWQD WIRRISIELL 1140 KESPSSALRS CSTLAGIYHP LARDLFNVSF LSCWDELTES NKKNLVKSIE LAMNAPNISV 1200 EILQTLLNLA EYMEREDHTL PIPIKVISAH ASKCNVYAKA LHYTELQFVQ ETKEEVSIST 1260 IESLITINNH LQQSDAAVGM LQYTKEHKQF SLKETWYEKL HRWDDALAAY EHREREGDSS 1320 FEINIGKLRC YYALGDWDHL SELAQKAWVT SEQEHREAIA PLAAAAAWGL GQWNLISEYV 1380 SAMDRDPQDK EFFSAISAVH LGQYNKAYGH IERHRDILVN DLSSIIGESY NRAYGIMVKS 1440 QMLSELEEII DYKKNMQYEN NLDSLKKTWR KRLEGCQKNV DVWHNTLRFR ALVLSPQDSP 1500 EMWIKLADLC RRSDRLKLSN QCLTYLMGRD PSNAYPLDSL KLLNPHVVYT YLKYLWATDQ 1560 KNIAVSELEE FTSYLSSKHG YKMGDSSKLV DILASSSVSS EERSFLARCF HKLGKWKKSL 1620 QDSVNQESVR DILNCYFYAT LFDKSWYKAW HSWALANFEV VGYYEQTEHG VTQDMYEQYI 1680 VPAIKGFFHS SVLNQKNSLQ DILRLLNLWF KFGEHSDVAA AIVEGFSNVP MDTWLEVIPQ 1740 LIARIHTSSS SVRASVHQLL SDIGRVHPQA LVYSLTVSSK STNPQQKHSA KSIMDSMLSH 1800 SDTLVRQALL VSQELIRVAI LWHELWYEGL EEASQAYFSD HDISLMIDIV KPLHETLEKG 1860 PSTLSEISFA QTFGYDLRKA RSYWQKFLQD GDPTELNQSW DLYYQVFRRI QKQLPRIKHL 1920 ELQYVSPKLL DACDLELAVP GTYGHNKPVI RISHFHHTFE VISSKQRPRR LTIHGSDGKD 1980 YQYVLKGHED LRQDERVMQL FGLCNTLLTT DSETFKRRLN IERYTVIPLS PNSGLLGWVP 2040 HSDTLHFLIK EFRSKRNILL NLEHRMMLQM APDCDSLTLL QKLEVFEYVM ANTDGYDLYH 2100 VLWLKSRSSE AWLDRRTSYT QSLAVMSMVG YILGLGDRHP SNLMMDRYSG KIIHIDFGDC 2160 FEVAMHREKF PEKIPFRLTR MLINAMEVSG IQGTYKITCE LVMRVLRSNT ESLMAVLEAF 2220 VYDPLINWRL MTKSSFGAST TLRPTSSSVE EKGRSYTHRA RHADYAALSE TNGVNAEGLN 2280 ERSIQVLKRV SNKLTGKDFD LKEQLPVKAQ VEKLIQQATA PENLCRCYVG WCSFW
2336Fasta Sequence
>O14356|tor1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) MEYFSDLKNKNESIQLAAADQLKEFVHSSTKELSGESLARFNNDINRRIFELIHSHDSHERFGGILAIGKLIEFESEGDVTNLSRYANYLRMTLPSTDWHSMELSAKVLGHLAASGGTLAAEFVEFEVQRAFEWLQGDRQEQKRMAAILIIKALAQNSPTLVYLYISEIFQNLWTGLRDPKPLIRETAADALGASLDVVCQREAKVQLQCFNEVLLQAEHGLRQSSVEYLHGSLLAYKELFEKSGSFIREHYTEFCDLALRLREHRDNSIRRCIVFLLPTLSEYNPKKFQQRYLDSFMVYLLSHIRKDKEKSLAFEAIGRIAMAVNEAMIPYLQNILKVIRDTLTAKVREKTQYEKPVFECIGMLAAAVKLELLEDSRSLLGLIFSCELSVHLRQALVKMAENIPPLLAPIQERLLNMVSQILTGKNFEIRTNDTYTPSFTNIYSAREPDQRSKSTESIILALETLGTFNFTGYSLISFIQESVLSYLENDNSEIRIAAARTCCQVFARDPICRKTNPLAVESVAEVLEKLLTLGIADSDPKIRETVLSLLDERFDRHLAHPDNIRCLFIALNDEVFSIREIAIIIIGRLALYNPAHVMPSLRKTIIQLLSDMEYSGNSRQKEESAQLLKLLVSKARTLIKPYIQSIIHVILPKAADTSPGVSSAIISALGELASVEGEDMPVDVRGSFMKLILVNLQDQSSTLKRLASLKCLRKLCGRSGYVIQPYLDYPPLLGALIGILQSEQPTPIRREVLRTLGVLGALDPYTYLTTEEVSDDLQSSHNNAHGVPQISAAQYPSLENYAMVAVVTLIGILKDSSLSMHHSSVVQAVMHICSQMGSKSTVFLPQVVPTFLQVMQSLSASSAEFYFQQLTTLTSIIGPNIRDYVSDIFNLSKVFWESTTSLLLVILELIDAIAIALQDEFKFYLPQILSCMLKAFSLDNTSSRSVSYKVLQSFVIFGSNIEEYMHLVLPVIIRSFERDTIPLGFRKSALKCIAQLFQSVNFSDHASRIIHPLVRMLGKSNGDLRAVIMDTLCAIVSQLGYDYSIFIPMVNKVLVSHKISHPAYELLVSRLLKGEPLPKDVVVKEFKPRPSTKPFSTQDEVLTKLPVDQASLKAAWESSQKLTRDDWQDWIRRISIELLKESPSSALRSCSTLAGIYHPLARDLFNVSFLSCWDELTESNKKNLVKSIELAMNAPNISVEILQTLLNLAEYMEREDHTLPIPIKVISAHASKCNVYAKALHYTELQFVQETKEEVSISTIESLITINNHLQQSDAAVGMLQYTKEHKQFSLKETWYEKLHRWDDALAAYEHREREGDSSFEINIGKLRCYYALGDWDHLSELAQKAWVTSEQEHREAIAPLAAAAAWGLGQWNLISEYVSAMDRDPQDKEFFSAISAVHLGQYNKAYGHIERHRDILVNDLSSIIGESYNRAYGIMVKSQMLSELEEIIDYKKNMQYENNLDSLKKTWRKRLEGCQKNVDVWHNTLRFRALVLSPQDSPEMWIKLADLCRRSDRLKLSNQCLTYLMGRDPSNAYPLDSLKLLNPHVVYTYLKYLWATDQKNIAVSELEEFTSYLSSKHGYKMGDSSKLVDILASSSVSSEERSFLARCFHKLGKWKKSLQDSVNQESVRDILNCYFYATLFDKSWYKAWHSWALANFEVVGYYEQTEHGVTQDMYEQYIVPAIKGFFHSSVLNQKNSLQDILRLLNLWFKFGEHSDVAAAIVEGFSNVPMDTWLEVIPQLIARIHTSSSSVRASVHQLLSDIGRVHPQALVYSLTVSSKSTNPQQKHSAKSIMDSMLSHSDTLVRQALLVSQELIRVAILWHELWYEGLEEASQAYFSDHDISLMIDIVKPLHETLEKGPSTLSEISFAQTFGYDLRKARSYWQKFLQDGDPTELNQSWDLYYQVFRRIQKQLPRIKHLELQYVSPKLLDACDLELAVPGTYGHNKPVIRISHFHHTFEVISSKQRPRRLTIHGSDGKDYQYVLKGHEDLRQDERVMQLFGLCNTLLTTDSETFKRRLNIERYTVIPLSPNSGLLGWVPHSDTLHFLIKEFRSKRNILLNLEHRMMLQMAPDCDSLTLLQKLEVFEYVMANTDGYDLYHVLWLKSRSSEAWLDRRTSYTQSLAVMSMVGYILGLGDRHPSNLMMDRYSGKIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLINAMEVSGIQGTYKITCELVMRVLRSNTESLMAVLEAFVYDPLINWRLMTKSSFGASTTLRPTSSSVEEKGRSYTHRARHADYAALSETNGVNAEGLNERSIQVLKRVSNKLTGKDFDLKEQLPVKAQVEKLIQQATAPENLCRCYVGWCSFW
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Keyword |
KW-0067--ATP-binding KW-0131--Cell cycle KW-0181--Complete proteome KW-0418--Kinase KW-0547--Nucleotide-binding KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0808--Transferase
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Interpro |
IPR011989--ARM-like IPR016024--ARM-type_fold IPR024585--DUF3385_TOR IPR003152--FATC_dom IPR011009--Kinase-like_dom IPR000403--PI3/4_kinase_cat_dom IPR018936--PI3/4_kinase_CS IPR003151--PIK-rel_kinase_FAT IPR014009--PIK_FAT IPR009076--Rapamycin-bd_dom IPR026683--TOR
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PROSITE |
PS51189--FAT PS51190--FATC PS00915--PI3_4_KINASE_1 PS00916--PI3_4_KINASE_2 PS50290--PI3_4_KINASE_3
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Pfam |
PF11865--DUF3385 PF02259--FAT PF02260--FATC PF00454--PI3_PI4_kinase PF08771--Rapamycin_bind
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0005829--C:cytosol GO:0031932--C:TORC2 complex GO:0016303--F:1-phosphatidylinositol-3-kinase activity GO:0005524--F:ATP binding GO:0008144--F:drug binding GO:0004674--F:protein serine/threonine kinase activity GO:0007569--P:cell aging GO:0007049--P:cell cycle GO:0006995--P:cellular response to nitrogen starvation GO:0071470--P:cellular response to osmotic stress GO:0000724--P:double-strand break repair via homologous recombination GO:0018105--P:peptidyl-serine phosphorylation GO:0048015--P:phosphatidylinositol-mediated signaling GO:0031139--P:positive regulation of conjugation with cellular fusion GO:0031929--P:TOR signaling
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