dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000641 | ||||||||
| Uniprot Accession | O14344; IMDH_SCHPO; P78758; Q9P3X8; | ||||||||
| Genbank Protein ID | NP_595702.1; | ||||||||
| Genbank Nucleotide ID | NM_001021599.2; | ||||||||
| Protein Name | Inosine-5'-monophosphate dehydrogenase | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | gua1 | ||||||||
| Gene Synonyms/Alias | SPBC2F12.14c; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSAFKPYTEA LEVLKKYEKK DGLSIDDLIR HNFQGGLTFN DFLILPGYID FVPNNVSLET 60 RISRNIVLKT PFMSSPMDTV TEDQMAIYMA LLGGIGVIHH NCTPEEQAAM VRKVKKYENG 120 FILDPVVFSP QHTVGDVLKI KETKGFSGIP ITENGKLRGK LVGIVTSRDV QFHKDTNTPV 180 TEVMTPREEL ITTAEGISLE RANEMLRKSK KGKLPVVDKD DNLVALLSLT DLMKNLHFPL 240 ASKTSDTKQL MVAAAIGTRD DDRTRLALLA EAGLDAVVID SSQGNSCFQI EMIKWIKKTY 300 PKIDVIAGNV VTREQTASLI AAGADGLRVG MGSGSACITQ EVMACGRPQA TAIAQVAEFA 360 SQFGIGVIAD GGIQNVGHMV KSLSLGATAV MMGGLLAGTT ESPGEYYVRE GQRYKSYRGM 420 GSIAAMEGTG VNKNASTGRY FSENDAVRVA QGVSGLVVDK GSLLRFLPYL YTGLQHALQD 480 IGTKSLDELH EAVDKHEVRF ELRSSAAIRE GDIQGFATYE KRLY 525 |
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| Keyword | KW-0129--CBS domain |
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| Interpro | IPR013785--Aldolase_TIM |
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| PROSITE | |||||||||
| Pfam | |||||||||
| Gene Ontology | GO:0005829--C:cytosol |