| Tag |
Content |
| dbPAF ID |
dbPAF-0000624 |
| Uniprot Accession |
O14289; LEUC_SCHPO;
|
| Genbank Protein ID |
NP_594576.1;
|
| Genbank Nucleotide ID |
NM_001020005.2;
|
| Protein Name |
3-isopropylmalate dehydratase |
| Protein Synonyms/Alias |
Alpha-IPM isomerase;IPMI;Isopropylmalate isomerase; |
| Gene Name |
leu2 |
| Gene Synonyms/Alias |
SPAC9E9.03; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.Functional Description
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MSPSVASPKT LYDKVWDSHV VDLQEDGTCL LYIDRHLIHE VTSPQAFEGL RTAGRKVRHP 60
ELALATVDHN IPTDPRKDMK DIASFIHQPD SRTQVLALEN NIKEFGLTYY GMNDRRQGIV 120
HVIGPEQGFT LPGTTLVCGD SHTSTHGAFG ALAFGIGTSE VEHVLATQTI LQRKSKNMRI 180
RVNGKLPEGI ASKDLILHII GVIGTAGGTG SVIEFCGEAI EGLSMEARMS MCNMSIEAGA 240
RAGMIAPDAT TFEYVKNRPL APKGDDWEQA VAYWKTLRSD ENAKYDIEVE INAADVLPTV 300
TWGTSPQDVI PINGNIPDPA HVKDNVRAAS IQRSLEYMGL KPNTSIVSYP IDKVFIGSCT 360
NSRIEDLRLA AAVVKGRKVA ANVKDAMIVP GSGLVKKMAE AEGLDQIFIE AGFDWREAGC 420
SMCLGMNPDQ LKPYERCAST SNRNFEGRQG AKGRTHLVSP AMAAAAAIKG HLCNVREFFG 480
DVSNGSPSII TNKNYDPSHD VEGDIGLSVD DATDAVTDAD GIATNVAGSV SSGSAGIPKF 540
TVVEGIAAPL PMANVDTDKI IPKQFLKTIK RTGLGQFAFY EIRYDADGKE IPDFVLNREP 600
YRHATVLVAH DNFGCGSSRE HAPWALNDFG IRVIIAPSFA DIFFNNCFKN GMLPIPTPIE 660
QVNDMMKAAE NQVKFSVDLV NQTITYGDKQ VKFDVEPFRK HCLVNGLDDI GLTLQKETMI 720
DAFEAAREEN FPWMNIKRSR ARLSPVKSNK QSSSRNDW
759Fasta Sequence
>O14289|leu2|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MSPSVASPKTLYDKVWDSHVVDLQEDGTCLLYIDRHLIHEVTSPQAFEGLRTAGRKVRHPELALATVDHNIPTDPRKDMKDIASFIHQPDSRTQVLALENNIKEFGLTYYGMNDRRQGIVHVIGPEQGFTLPGTTLVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQRKSKNMRIRVNGKLPEGIASKDLILHIIGVIGTAGGTGSVIEFCGEAIEGLSMEARMSMCNMSIEAGARAGMIAPDATTFEYVKNRPLAPKGDDWEQAVAYWKTLRSDENAKYDIEVEINAADVLPTVTWGTSPQDVIPINGNIPDPAHVKDNVRAASIQRSLEYMGLKPNTSIVSYPIDKVFIGSCTNSRIEDLRLAAAVVKGRKVAANVKDAMIVPGSGLVKKMAEAEGLDQIFIEAGFDWREAGCSMCLGMNPDQLKPYERCASTSNRNFEGRQGAKGRTHLVSPAMAAAAAIKGHLCNVREFFGDVSNGSPSIITNKNYDPSHDVEGDIGLSVDDATDAVTDADGIATNVAGSVSSGSAGIPKFTVVEGIAAPLPMANVDTDKIIPKQFLKTIKRTGLGQFAFYEIRYDADGKEIPDFVLNREPYRHATVLVAHDNFGCGSSREHAPWALNDFGIRVIIAPSFADIFFNNCFKNGMLPIPTPIEQVNDMMKAAENQVKFSVDLVNQTITYGDKQVKFDVEPFRKHCLVNGLDDIGLTLQKETMIDAFEAAREENFPWMNIKRSRARLSPVKSNKQSSSRNDW
|
| Keyword |
KW-0004--4Fe-4S
KW-0028--Amino-acid biosynthesis
KW-0100--Branched-chain amino acid biosynthesis
KW-0181--Complete proteome
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0432--Leucine biosynthesis
KW-0456--Lyase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR004430--3-IsopropMal_deHydase_lsu
IPR004431--3-IsopropMal_deHydase_ssu
IPR012235--3-IsopropMal_deHydtase_ssu/lsu
IPR015931--Acnase/IPM_dHydase_lsu_aba_1/3
IPR015937--Acoase/IPM_deHydtase
IPR001030--Acoase/IPM_deHydtase_lsu_aba
IPR015928--Aconitase/3IPM_dehydase_swvl
IPR015932--Aconitase/IPMdHydase_lsu_aba_2
IPR018136--Aconitase_4Fe-4S_BS
IPR000573--AconitaseA/IPMdHydase_ssu_swvl
|
| PROSITE |
PS00450--ACONITASE_1
PS01244--ACONITASE_2
|
| Pfam |
PF00330--Aconitase
PF00694--Aconitase_C
|
| Gene Ontology |
GO:0009316--C:3-isopropylmalate dehydratase complex
GO:0005829--C:cytosol
GO:0003861--F:3-isopropylmalate dehydratase activity
GO:0051539--F:4 iron, 4 sulfur cluster binding
GO:0046872--F:metal ion binding
GO:0009098--P:leucine biosynthetic process
|
