dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000617
Uniprot Accession O14261; ATG11_SCHPO;
Genbank Protein ID NP_593855.1;
Genbank Nucleotide ID NM_001019284.2;
Protein Name Taz1-interacting factor 1
Protein Synonyms/Alias
Gene Name taf1
Gene Synonyms/Alias atg11;cvt9;SPAC7D4.04;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the preautophagosome (PAS), the site of vesicle/autophagosome formation. Required for atg9 anterograde transport from the mitochondria to the PAS (By similarity). Required for nitrogen starvation-induced sexual development and for entering the dormant G0 state (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
459EYLGFPGSPREAVSNdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
530SQPFYRVSPSIVPLNdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
548KLTNRKTSFTDSHILdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
550TNRKTSFTDSHILRLdbPTM 3.0;UniProt18257517; 16381945; 23193290
552RKTSFTDSHILRLQDdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
744VTQPGFDSDNERDGHdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MRFRLNDSFS GKSWTIDNVQ WTPQNLVAWI MELNIGLSDE AKLLLPNGMS LNETVLNSES 60
DVVIYVLDQN LLTFTYDGDK IPSIPSLKGQ PISNVLTGII ADSSSDQWKD KISKCLSLLS 120
DILESSSKIH NQLSVCHDEY STSIVSPEVA MNYLQRRQSG MKDLLFVFYE RLDRVSVSDL 180
LHDFLALPTG SLPITPLKIL STNWTKLDSW LNSISARYAE AQKRVQQCIG AANSIIVSPF 240
KEVPSIKEGD DAYYHLRSVA QDAANILQEI LKIESTSTTS QIKPKCNYET EITDCMEKLQ 300
SNLSELKSSR KSSLISLKSF WLSFYKVSLR YDALYEYLRQ IAEELDRSKF VLSQSRNIFS 360
LYIDILMEAL RRTEWQESYN VSHDSSLPLD QEKELSLRKS WLSHFSNLLF NHGQLKYLPV 420
LTRDEISNYL LNIQAHPNYQ TFHQMLSNRL SEYLGFPGSP REAVSNTVQA NNSLHEKLAM 480
YQNRCNNLEA MLSHQNGFNY NINNDGLSPN APHPPINEQS NSSQPFYRVS PSIVPLNVIR 540
KLTNRKTSFT DSHILRLQDE VNQLRNELDL VNKRNEDLLI ELQGKEEKIQ YLETENEEVL 600
QKYENLQEEL SSTRKLLTKN EAAVAEQQSN EEMHSNEPNI LNLYSVFEGK VDSLQELYNA 660
FKLQLTSLKQ KGEYATLAKD AEAVQHIIEE RDYALAEKAD LLKLSENRKE QCKILTQKLY 720
TIVFRCNELQ SVLRECVTQP GFDSDNERDG HASIPDRQIE FNSKDLQYLY WMDGEDADRN 780
FQEFLNRMSS LDFDSFHNFV VSVLTQAHNH ELRWKREFQS NRDKALKAIL DSQSKVSLRN 840
FKQGSLVLFL PTRRTAGNKK VWAAFNVNAP HYYLNTQPHL KLESRDWMLG RVTSIEDRTA 900
DDSTDKWLRL PSGTIWHLVE AIDERF 927
Keyword

KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0926--Vacuole
Interpro

IPR019460--Autophagy-rel_p11
PROSITE
Pfam

PF10377--ATG11
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019898--C:extrinsic component of membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0005634--C:nucleus
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0006995--P:cellular response to nitrogen starvation
GO:0032258--P:CVT pathway
GO:0031142--P:induction of conjugation upon nitrogen starvation
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0034497--P:protein localization to pre-autophagosomal structure