dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000610 | ||||||||
| Uniprot Accession | O14240; EAF6_SCHPO; | ||||||||
| Genbank Protein ID | NP_593902.1; | ||||||||
| Genbank Nucleotide ID | NM_001019332.2; | ||||||||
| Protein Name | Chromatin modification-related protein eaf6 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | eaf6 | ||||||||
| Gene Synonyms/Alias | SPAC6F6.09; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSTPNSTPSE PPVNVSYYEQ CKKELHEMIE KRQLLETSLI GLEDSIYRLE GSYLEKTSGT 60 GNIIRGFEGL LKNNASNLRR RADYSESDRL FSLSSLSSPH TRSPAYDLDD STETSRRRKR 120 KNESDSHEGR RRSSFREL 139 |
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| Keyword | KW-0156--Chromatin regulator |
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| Interpro | IPR015418--Hist_AcTrfase_NuA4_cplx |
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| PROSITE | |||||||||
| Pfam | PF09340--NuA4 |
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| Gene Ontology | GO:0005829--C:cytosol |