dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000594
Uniprot Accession O14188; RNG2_SCHPO; Q9USG0;
Genbank Protein ID NP_593860.1;
Genbank Nucleotide ID NM_001019289.2;
Protein Name Ras GTPase-activating-like protein rng2
Protein Synonyms/Alias Ring assembly protein 2;
Gene Name rng2
Gene Synonyms/Alias SPAC4F8.13c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Required for cytokinesis. Component of the contractile F-actin ring; required for its construction following assembly of F-actin at the division site.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
23APVGTKGSNTRLAAKcurated22817900
Sequence
(Fasta)		MDVNVGLSRL QSQAGAPVGT KGSNTRLAAK QRETLQAYDY LCRVDEAKKW IEECLGTDLG 60
PTSTFEQSLR NGVVLALLVQ KFQPDKLIKI FYSNELQFRH SDNINKFLDF IHGIGLPEIF 120
HFELTDIYEG KNLPKVIYCI HALSYFLSMQ DLAPPLIKSD ENLSFTDEDV SIIVRRLRQS 180
NVILPNFKAL SADFMLRASP VSSRTPSPTR FPKHARFQTL NSSDSASIYS SPYTSPTLEF 240
SKKDASARSD ILKMHRRTKS ATPSLEQFNE PYKQTLPSHS IEFEDSFFQP PSQKGHMQRS 300
FLTTFSAPTR RREALFSTTS GLSQRSPVDE KIVNAIQACG RGVLVRLRLV DMLQSLVEQS 360
SSVVLLQAVI RGYISRNTYR IRKKAYDELV NWVTSIQSIS RAYLIRAQYR KVVLQEEATK 420
SIQTLQSIIR GGFYRRKYHS LIERLDLFTP SFVLIQSSAL GFLTRHAIVN MLDNLYNYIP 480
LFNRMQSILR ANMFRNEWSN FLDSVQSFPV SFHSICKGRL IRDSINRLNG SLLGELDNFI 540
KLQNLSRGFM IRRAFKEKLE KLKASTSSFI ALQAIVRAFL LRKNLESIYD SFQKSHLSVI 600
KAQSLYRGFI TRTKIDYCND YLLKRLPDIV FMQSAVRAIL LRDDVNYTEV QLDSFIPEIV 660
LLQSLIRGYL SRNKFSRKLQ NFHKNMENPI VAKSIFRGRQ EGLAYRELAT AKNPPVMTVK 720
NFVHLLDDTN FDFEEEVLLE KMRKEIVQQV RDNEEIEVHI NELDVKIALL VKNKISLDDV 780
LKHHNKYKFG KQSTEYLKIN TLSMKSLNNS SRKFLELYQC FFYVLQTNEM YLANYFQALK 840
TEGTSSVKIR HAVYLVLQIF GHGSNRREEV LLLRFISQVI KLEAALVNSS QDLLSDDCVW 900
KLLFTGYRGD VREVKLWKTI LGRIHKVLVA DNHLDFEINP LTLFKSFNPE VASQTDSPKL 960
TLSLAMQHPP TRNLYVSRLR ELRKLCQSFL VALSKNIENI PYALCYTAAQ LKNSLQRYFP 1020
AAHKEEIFGV IGKFVYWAYV APVLVSPDNF KLVDGSITAL QRKNLYTLSS ILSEIFSIES 1080
CDSKQLGFFR PLSEFIEVSK QDTMLMLERL VDVVDPEVYF EFDAFEDLVN TKRPVIYMKR 1140
DDILGIYSSI AYVIDSIAPP DVNDPLRAVV NSLGPVSEQD NDFVQDETDV KLELNPKFCT 1200
IENPVAQERT LIVQTKRYIL FIIRIQNGLN LLEILVKPVT DSDEAAWQNL LAEESEKNAR 1260
NYDLFDDSIF SMSFAELKYT ALSNIVEMEK LGFANRRNNY QDMVNSIALD IRNKSRRRMQ 1320
RQRELDAGHQ SLLNLREKRA FLDSQLKSYN EYIEQAMETL QSKKGKKKLI PFSKQYFHMR 1380
DLRKSGRVPR FGSFKYPALK LYDRGVLVSI SHMPQKEKLY ITISADEVGK FILEATSPTV 1440
KVSSPRCELH LDDLLSAQYN KVLTLDVLDG RLKLNTNMFL HLIFSKFYS
Keyword

KW-0002--3D-structure
KW-0112--Calmodulin-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0717--Septation
Interpro

IPR001715--CH-domain
IPR000048--IQ_motif_EF-hand-BS
IPR000593--RasGAP_C
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot
PROSITE

PS50021--CH
PS50096--IQ
PS50018--RAS_GTPASE_ACTIV_2
Pfam

PF00307--CH
PF00612--IQ
PF00616--RasGAP
PF03836--RasGAP_C
Gene Ontology

GO:0005826--C:actomyosin contractile ring
GO:0005737--C:cytoplasm
GO:0071341--C:medial cortical node
GO:0044732--C:mitotic spindle pole body
GO:0005635--C:nuclear envelope
GO:0005816--C:spindle pole body
GO:0003779--F:actin binding
GO:0005516--F:calmodulin binding
GO:0005096--F:GTPase activator activity
GO:1903478--P:actin filament bundle convergence involved in mitotic contractile ring assembly
GO:0000917--P:barrier septum assembly
GO:1903475--P:mitotic actomyosin contractile ring assembly
GO:1903479--P:mitotic actomyosin contractile ring assembly actin filament organization
GO:1902405--P:mitotic actomyosin contractile ring localization
GO:1903477--P:mitotic contractile ring actin filament bundle assembly
GO:0000281--P:mitotic cytokinesis
GO:0071574--P:protein localization to medial cortex
GO:0007264--P:small GTPase mediated signal transduction