dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000593 | ||||||||
| Uniprot Accession | O14187; SPP42_SCHPO; | ||||||||
| Genbank Protein ID | NP_593861.1; | ||||||||
| Genbank Nucleotide ID | NM_001019290.2; | ||||||||
| Protein Name | Pre-mRNA-splicing factor spp42 | ||||||||
| Protein Synonyms/Alias | Complexed with cdc5 protein 6; | ||||||||
| Gene Name | spp42 | ||||||||
| Gene Synonyms/Alias | cwf6;SPAC4F8.12c; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MASLPPGNPP PPPPPPGFEP PSQPPPPPPP GYVKKRKNKT PAQSGNLEKQ LNERARKWRA 60 SQKSKFGVKR KQGYVQTEKA DLPPEHLRKI MKDRGDMSSR KFRADKRSYL GALKYLPHAV 120 LKLLENMPMP WEEYREVKVL YHVTGAITFV NESPRVIEPH FIAQWGTMWM MMRREKRDRK 180 NFKRLRFPPF DDEEPPFSID QLLDLEPLEA IRMDLDEEDD APVMDWFYEN KALEDTPHVN 240 GPTYRRWKLN LPQMANLHRL GYQLLSDLRD DNYFYLFNDN SFFTAKALNV AIPGGPKFEP 300 LYKDEAPEME DWNEFNDIYK LIIRHPIKTE YRIAFPYLYN SRARSVALSE YHQPSNVFVP 360 PEDPDLPAFF WDPIINPITS RQLTLHELDT SPEDSAIEED PNFEIPFDPF FHSEDIEFEH 420 TASALILLWA PHPFNKRSGA TKRAQDVPLI KHWYLEHCPP NQPVKVRVSY QKLLKSHVMN 480 KLHMAHPKSH TNRSLLRQLK NTKFFQSTSI DWVEAGLQVC RQGYNMLQLL IHRKGLTYLH 540 LDYNCNLKPT KTLTTKERKK SRFGNAFHLM REILRLTKLI VDSHVQYRLG NIDAYQLADG 600 LHYIFNHVGQ LTGMYRYKYR LMRQIRACKD FKHLIYYRFN TGPVGKGPGC GFWAPSWRVW 660 LFFLRGIVPL LERWLGNLLA RQFEGRHSTG VAKQITKQRV DSHQDLELRA AVMNDILDMI 720 PEGIRQGKSK TILQHLSEAW RCWKANIPWK VPGLPAPIEN MILRYVKSKA DWWTSVAHFN 780 RERIRRGATV DKTVAKKNLG RLTRLWLKAE QERQHNYLKD GPYVTADEAV AIYTTFVHWL 840 ESRRFQPIPF PPLSYKHDTK LLVLALERLK EAYSVKGRLN QSQREELALV EQAYDNPHEM 900 LSQIKRRLLT MRTFKEVGIE FMDMYSHLIP VYSVDPMEKI CDAYLDQYLW FEADRRHLFP 960 SWVKPSDSEP PPLLVYKWCQ GINNLTDVWE TSNGECNVLM ETRLSKVFEK VDLTLLNRLM 1020 SLLMDTNLAS YASAKNNVVL SYKDMSHTNS YGLVRGLQFS SFIWQFYGLV LDLLILGLQR 1080 ATEIAGPADA PNDFLHFKDQ ATETSHPIRL YTRYIDKVYI MFRFTDEESR DLIQRFLNEN 1140 PDPTNSNVVN YSKGKKNCWP RDARMRLMKH DVNLGRAVFW EIRNRLPRSL TTLEWEDTFP 1200 SVYSKDNPNL LFSMTGFEVR ILPKIRQNEE FSLKDGVWNL TDNRTKQRTA QAFIRVTEDG 1260 INQFGNRIRQ ILMSSGSTTF TKIANKWNTA LIALMTYYRE AAISTPELLD LLVKCESKIQ 1320 TRVKISLNSK MPSRFPPAVF YSPKELGGLG MLSMGHVLIP QSDLRWSKQT DTGITHFRSG 1380 MTTNGEHLIP NLYRYIQPWE SEFIDSQRVW AEYAMKRQEA LQQNRRLTLE DLEDSWDRGI 1440 PRINTLFQKD RHTLAYDKGW RVRTEFKQYQ LLKNNPFWWT SQRHDGKLWQ LNNYRVDVIQ 1500 ALGGVEGILE HTMFKATGFP SWEGLFWEKA SGFEESMKFK KLTNAQRSGL NQIPNRRFTL 1560 WWSPTINRAN VYVGFQVQLD LTGIMMHGKI PTLKISLIQI FRSHLWQKIH ESVVWDLCQV 1620 LDQELESLQI ETVQKETIHP RKSYKMNSSC ADILLLAAYK WNVSRPSLLN DNRDVLDNTT 1680 TNKYWIDVQL RFGDYDSHDI ERYTRAKFLD YSTDAQSMYP SPTGVLIGID LCYNMHSAYG 1740 NWIPGMKPLI QQSMNKIMKA NPALYVLRER IRKGLQLYAS EPQEQYLSSS NYAELFSNQI 1800 QLFVDDTNVY RVTIHKTFEG NLTTKPINGA IFIFNPRTGQ LFLKVIHTSV WAGQKRLGQL 1860 AKWKTAEEVA ALIRSLPVEE QPRQIIVTRK GMLDPLEVHL LDFPNITIKG SELQLPFQAI 1920 IKLDKINDLI LRATEPQMVL FNLYDDWLQS VSSYTAFSRL ILILRALNVN TEKTKLILRP 1980 DKSIITKENH VWPNLDDQQW LDVEPKLRDL ILADYAKKNN INVASLTNSE VRDIILGMTI 2040 TAPSLQRQQI AEIEKQGREN AQVTAVTTKT TNVHGDEMVV TTTSAYENEK FSSKTEWRNR 2100 AISSISLPLR TKNIYVNSDN ISETFPYTYI LPQNLLRKFV TISDLRTQVA GYMYGKSPSD 2160 NPQIKEIRCI ALVPQLGSIR NVQLPSKLPH DLQPSILEDL EPLGWIHTQS SELPYLSSVD 2220 VTTHAKILSS HPEWDTKAVT LTVSYIPGSI SLAAYTVSKE GIEWGSKNMD INSDEAIGYE 2280 PSMAEKCQLL LSDRIQGFFL VPEEGVWNYN FNGASFSPKM TYSLKLDVPL PFFALEHRPT 2340 HVISYTELET NDRLEEDMPD AFA 2364 |
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| Keyword | KW-0002--3D-structure |
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| Interpro | IPR000555--JAMM/MPN+_dom |
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| PROSITE | |||||||||
| Pfam | PF01398--JAB |
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| Gene Ontology | GO:0071013--C:catalytic step 2 spliceosome |